Dr. Chanakya Nath Kundu
Professor
Ph. D. Jadavpur University, 2002
M.Sc. Kalyani University, 1997


Email : [email protected]

Postdoctoral Experience

2001 - 2005       Texas A & M University, Temple, Texas, USA.
2005 – 2007      UF Shands Cancer Center, University of Florida, Gainesville, Florida, USA.
2007 - 2008       Cleveland Clinic Foundation, Department of Cancer Biology, Cleveland, OH, USA.

Research Interest

Understanding the metastasis and drug resistance of cancer cells are two of the key unresolved issues to improve therapeutic success. Till now the main option for cancer treatment is chemotherapy after surgery and radiation. The major focus of my research is to decipher the molecular mechanism of drug resistance of cancer and find out novel small molecule inhibitors which will inhibit the cancer cell growth, metastasis, self renewal property without affecting the normal cell niche. Dr Kundu has published more than 35 research articles in reputed international journal in following area.

  1. Evaluation of anti cancer potentiality of small molecule synthetic/bioactive / metal nano particle in pre clinical model in cancer cells.
  2. Improvement of sensitivity of a known anti-cancer drug by manipulating  specific  cell signaling cascade
  3. Study the cell transformation mechanism by continuous exposure to carcinogen from active and passive cigarette smoke in normal cells.
  4. Development of cancer specific markers for disease diagnosis and treatment.

Awards/Honours

  • Best faculty award at KIIT, 65 th Republic day, 2014
  • DBT-CREST Award 2012-13, visiting as a visiting professor at University of Pittsburgh,  Pittsburgh, PA, USA (from Jan 2104-July 2014)
  • Best MID LEVEL SCIENTIST award at Indian Association for Cancer Research 2013 (IACR-2013) held on ACBR New Delhi, held on 13-16 th February, 2013
  • International Fellowship Award for Young Biomedical Scientist 2010-11 by ICMR,  Govt of India, New Delhi ( Visited University of South Carolina, Carolina, USA as a visiting professor (Feb 2011-May 2011)
  • Young Investigator Award –In 20th Asia Pacific Cancer Conference, held in Tsukuba, Ibraki, Japan on 14-16th November 2009.

Patent

  • N-Fused Aminoimidazoles as Novel Topoisomerase IIα-Targeting Anticancer Agents.  Guchhait SK, Kundu CN, Banerjee UC, Baviskar A,  Madaan C,  Agarwal A,  Preet R, Mohapatra P. Appl # 91/DEL/2011.

Selected Publications

Full List
  1. Mohapatra P, Satapathy SR, Das D, Siddharth S, Choudhuri T, Kundu CN*. Resveratrol mediated cell death in cigarette smoke transformed breast epithelial cells is through induction of p21Waf1/Cip1 and inhibition of long patch base excision repair pathway. Toxicol Appl Pharmacol. 2014,15;275(3):221-31.
  2. Mohapatra P, Preet R, Das D, Satapathy SR, Siddharth S, Choudhuri T, Wyatt MD, Kundu CN*. The contribution of heavy metals in cigarette smoke condensate to malignant transformation of breast epithelial cells and in vivo initiation of neoplasia through induction of a PI3K-AKT-NFκB cascade. Toxicol Appl Pharmacol. 2014, 1;274(1):168-79.
  3. Satapathy SR, Mohapatra P, Preet R, Das D, Sarkar B, Choudhuri T, Wyatt MD, Kundu CN*. Silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53. Nanomedicine (Lond). 2013, 8(8):1307-22.
  4. Preet R, Mohapatra P, Das D, Satapathy SR, Choudhuri T, Wyatt MD, Kundu CN*. Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC. Carcinogenesis. 2013, 34(2):277-86
  5. Preet R, Mohapatra P, Mohanty S, Sahu SK, Choudhuri T, Wyatt MD, Kundu CN*. Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity. Int J Cancer. 2012 Apr 1;130(7):1660-70

My lab is currently focusing on signaling aspects of molecular cancer biology in following area 1) Screening and study the mechanism of the anti cancer potentiality of multiple bioactive and synthetic compound in vitro and in vivo. ii) study the cancer causing mechanism by exposure to active and passive cigarette smoke carcinogen iii) increase the potentiality of widely used chemotherapeutic agent 5-fluorouracil by novel approaches iv) study the mechanism of anti-cancer potentiality of silver based nanoparticle in vivo and in vitro v) find out the potential biomarker for cancer stem cells in vivo and in vitro.

Completed -03

  1. ICMR : 30,00,000 INR
    Evaluation of anti-cancer potentiality of bio-active compound quinacrine in preclinical models of breast cancer
    Status: August 2009- August 2012
  2. ICMR- 30,00,000 INR
    Improvement of 5 flurouracil mediated cytotoxicity of colon cancer cells by novel approaches
    Status- April 2010- March13
  3. DBT-35,00,000, INR (collaboration with Institute of Life Science, Bhubaneswar, Orissa)
    Evaluate the mechanism of resveratrol mediated apoptosis in cigarette smoke induced breast cancer
    Status- April 2010- March13

ONGOING -01

  1. ICMR- Development of a potent anti-cervical cancer drug using bioactive small molecule Quinacrine- nanoparticle
    Funded -2013-16

Dr. Dr. Michael D. Wyatt; University of South Carolina, Columbia, SC, USA.

Dr. R W Sobol, University of Pittsburgh, University of Pittsburgh Cancer Institute,  Pittsburgh, PA, USA

Dr. Tathagata Choudhuri;  Visva Bharati University, West Bengal, India.

Dr. Shankar K Guchhait; NIPER, Mohali, Punjab, India.

Dr. C.R. Patil ; R.C. Patel College of Pharmacy, Maharashtra, India.

Dr.C.Chowdhury; Indian Institute of Chemical Biology, Jadavpur, Kolkata

Lab Members

 
  1. Das S, Tripathi N, Preet R, Siddharth S, Nayak A, Bharatam PV, Kundu CN*. Quinacrine induces apoptosis in cancer cells by forming a functional bridge between TRAIL-DR5 complex and modulating the mitochondrial intrinsic cascade. Oncotarget. 2016 Aug 17. (IF 6.4)
  2. Chanchal SK, Mahajan UB, Siddharth S, Reddy N, Goyal SN, Patil PH, Bommanahalli BP, Kundu CN*, Patil CR, Ojha S. In vivo and in vitro protective effects of omeprazole against neuropathic pain. Sci Rep. 2016 Jul 20;6: 30007. (IF 5.67)
  3.  Siddharth S, Das S, Nayak A, Kundu CN. SURVIVIN as a marker for quiescent-breast cancer stem cells-An intermediate, adherent, pre-requisite phase of breast cancer metastasis. Clin Exp Metastasis. 2016 Jul 13. [Epub ahead of print] (IF 2.9)
  4.  Priyadarshani G, Amrutkar S, Nayak A, Banerjee UC, Kundu CN*, Guchhait SK. Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα. Eur J Med Chem. 2016 Oct 21;122:43-54. (IF 3.5)
  5. Siddharth S, Nayak D, Nayak A, Das S, Kundu CN*. ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli. DNA Repair (Amst). 2016 Sep; 45:44-55. (IF 3.9)
  6. Sahu SK, Chakrabarti S, Roy SD, Baishya N, Reddy RR, Suklabaidya S, Kumar A, Mohanty S, Maji S, Suryanwanshi A, Rajasubramaniam S, Asthana M, Panda AK, Singh  SP, Ganguly S, Shaw OP, Bichhwalia AK, Sahoo PK, Chattopadhyay NR, Chatterjee K,  Kundu CN, Das AK, Kannan R, Zorenpuii, Zomawia E, Sema SA, Singh YI, Ghosh SK, Sharma K, Das BS, Choudhuri T. Association of p53 codon72 Arg>Pro polymorphism with susceptibility to nasopharyngeal carcinoma: evidence from a case-control study and meta-analysis. Oncogenesis. 2016 May 9;5:e225. (IF 5.2)
  7. Preet R, Siddharth S, Satapathy SR, Das S, Nayak A, Das D, Wyatt MD, Kundu CN*. Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade.  Biochem Pharmacol.  2016.  105:23-33  (IF 5.09)
  8. Nayak A, Satapathy SR, Das D, Siddharth S, Tripathi N, Bharatam PV, Kundu CN*. Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1. Sci Rep. 2016  Feb 5;6:20600. (IF 5.67)
  9. Satapathy SR, Mohapatra P, Das D, Siddharth S, Kundu CN*. The apoptotic effect of plant based nanosilver in colon cancer cells is a p53 dependent process involving ROS and JNK cascade. Pathol. Oncol. Res., 2014. Accepted on 13th August 2014.(* Corresponding author).
  10. Preet R, Chakraborty B, Siddharth S, Mohapatra P, Das D, Satapathy SR, Das S, Maiti NC, Maulik PR, Kundu CN*, Chowdhury C. Synthesis and biological evaluation of andrographolide analogues as anti-cancer agents. Eur J Med Chem. 2014, 24;85C:95-106. (* Corresponding author).
  11. Kumar A, Sahu SK, Mohanty S, Chakrabarti S, Maji S, Reddy RR, Jha AK, Goswami C, Kundu CN, Rajasubramaniam S, Verma SC, Choudhuri T. Kaposi sarcoma herpes virus latency associated nuclear antigen protein release the G2/M cell cycle blocks by modulating ATM/ATR mediated checkpoint pathway. PLoS One. 2014 Jun 27;9(6):e100228.
  12. Mohapatra P, Satapathy SR, Das D, Siddharth S, Choudhuri T, Kundu CN*. Resveratrol mediated cell death in cigarette smoke transformed breast epithelial cells is through induction of p21Waf1/Cip1 and inhibition of long patch base excision repair pathway. Toxicol Appl Pharmacol. 2014, 15;275(3):221-31. (* Corresponding author).
  13. Siddharth S, Mohapatra P, Preet R, Das D, Satapathy SR, Choudhuri T, Kundu CN. Induction of apoptosis by 4-(3-(tert-butylamino)imidazo[1,2-α]pyridine-2-yl) benzoic acid in breast cancer cells via upregulation of PTEN. Oncol Res. 2013;21(1):1-13. (* Corresponding author).
  14. Sahu SK, Mohanty S, Kumar A, Kundu CN, Verma SC, Choudhuri T. Epstein-Barr virus nuclear antigen 3C interact with p73: Interplay between a viral oncoprotein and cellular tumor suppressor. Virology. 2014, 5;448:333-43.
  15. Das D, Preet R, Mohapatra P, Satapathy SR, Kundu CN*. 1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells. World J Gastroenterol. 2013, 14;19(42):7374-88. (* Corresponding author).
  16. Mohapatra P, Preet R, Das D, Satapathy SR, Siddharth S, Choudhuri T, Wyatt MD, Kundu CN*. The contribution of heavy metals in cigarette smoke condensate to malignant transformation of breast epithelial cells and in vivo initiation of neoplasia through induction of a PI3K-AKT-NFκB cascade. Toxicol Appl Pharmacol. 2014, 1;274(1):168-79. (* Corresponding author).
  17. Kandekar S, Preet R, Kashyap M, Renu Prasad MU, Mohapatra P, Das D, Satapathy SR, Siddharth S, Jain V, Choudhuri M, Kundu CN*, Guchhait SK, Bharatam PV. Structural elaboration of a natural product: identification of 3,3'-diindolylmethane aminophosphonate and urea derivatives as potent anticancer agents. ChemMedChem. 2013, 8(11):1873-84. (* Corresponding author).
  18. Satapathy SR, Mohapatra P, Preet R, Das D, Sarkar B, Choudhuri T, Wyatt MD, Kundu CN*. Silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53. Nanomedicine (Lond). 2013, 8(8):1307-22. (* Corresponding author).
  19. Kashyap M, Kandekar S, Baviskar AT, Das D, Preet R, Mohapatra P, Satapathy SR, Siddharth S, Guchhait SK, Kundu CN*, Banerjee UC. Indenoindolone derivatives as topoisomerase II-inhibiting anticancer agents. Bioorg Med Chem Lett. 2013, 15;23(4):934-8. (* Corresponding author).
  20. Chaudhary G, Kundu CN*. Induction of a C-Repeat Binding Factor Gene by Calcium to resist Low Temperature stress in rice,  Int. J. P, P, Biochem. 2012,4(6), 142-145, Impact Factor 1.48) (*Corresponding author)
  21. Mohapatra P, Preet R, Das D, Satapathy SR, Choudhuri T, Wyatt MD, Kundu CN*. Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism. Oncol Res. 2012;20(2-3):81-91. (* Corresponding author).
  22. Preet R, Mohapatra P, Das D, Satapathy SR, Choudhuri T, Wyatt MD, Kundu CN*. Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC. Carcinogenesis. 2013, 34(2):277-86. (* Corresponding author).
  23. Kashyap M, Das D, Preet R, Mohapatra P, Satapathy SR, Siddharth S, Kundu CN*, Guchhait SK. Scaffold hybridization in generation of indenoindolones as anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2474-9. (* Corresponding author).
  24. Das D, Preet, R, Mohapatra P, Satapathy SR, Kundu CN* In Silico model of Homo sapiens Nectin-4: a novel anticancer drug target, Online J Bioinformatics. (2011); 12(2):395-412,  (*Corresponding author).
  25. Mohapatra P, Preet R, Choudhuri M, Choudhuri T, Kundu CN*. 5-fluorouracil increases the chemopreventive potentials of resveratrol through DNA damage and MAPK signaling pathway in human colorectal cancer cells. Oncol Res. 2011;19(7):311-21. (* Corresponding author).
  26. Baviskar AT, Madaan C, Preet R, Mohapatra P, Jain V, Agarwal A, Guchhait SK, Kundu CN*, Banerjee UC, Bharatam PV. N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIα and induce apoptosis in G1/S phase. (Indian patent, 91/DEL/2011). J Med Chem. 2011 Jul 28;54(14):5013-30. (* Corresponding author).
  27. Preet R, Mohapatra P, Mohanty S, Sahu SK, Choudhuri T, Wyatt MD, Kundu CN*. Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity. Int J Cancer. 2012 Apr 1;130(7):1660-70. (* Corresponding author).
  28. Kundu CN, jiang Y, Howe PH, Houghton JA. Regulation of components of Wnt signaling following 5 FU flurouracil/lecoverin induced DNA damage in human colon carcinoma cell lines. (MS under preparation)
  1. Kundu CN, Guo Y, Jani TS, Yang K, Houghton JA. P21 and checkpoint kinases play an important role in thymidylate synthase (TS) dependent cell death in human colon cancer cell lines ( MS under preparation).
  2. Kundu CN*, Sondarva G*,  Mehrotra S, Mishra R, Rangasamy V, Sathyanarayana P, Ray RS, Rana B, Rana A. TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation. Cell Res. 2010, 20(1):89-98. (* Equal contribution)
  3. Connors SK, Balusu R, Kundu CN, Jaiswal AS, Gairola CG, Narayan S. C/EBPbeta-mediated transcriptional regulation of bcl-xl gene expression in human breast epithelial cells in response to cigarette smoke condensate. Oncogene. 2009, 12;28(6):921-32.
  4. Balusu R, Jaiswal AS, Armas ML, Kundu CN, Bloom LB, Narayan S. Structure/function analysis of the interaction of adenomatous polyposis coli with DNA polymerase beta and its implications for base excision repair. Biochemistry. 2007, 11;46(49):13961-74.
  5. Kundu CN, Balusu R, Jaiswal AS, Narayan S. Adenomatous polyposis coli-mediated hypersensitivity of mouse embryonic fibroblast cell lines to methylmethane sulfonate treatment: implication of base excision repair pathways. Carcinogenesis. 2007, 28(10):2089-95.
  6. Kundu CN, Balusu R, Jaiswal AS, Gairola CG, Narayan S. Cigarette smoke condensate-induced level of adenomatous polyposis coli blocks long-patch base excision repair in breast epithelial cells. Oncogene. 2007, 1;26(10):1428-38.
  7. Jaiswal AS, Balusu R, Armas ML, Kundu CN, Narayan S. Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair. Biochemistry. 2006, 26;45(51):15903-14.
  8. Das K, Kundu CN, Chakrabarty J, Dutta P, Bhattacharyya D, Ghosh A, Majumder GC Factors influencing cryopreservation of mature goat epididymal sperm forward motility. Ind. J. Cryog. (2005); 30, 191-196
  9. Kundu CN, Das K, Chakrabarty J, Dutta P, Bhattacharyya D, Saha S, Ghosh A, Majumder G.C. Development of a novel epididymal sperm model for evaluating cryoprotecting potential of various reagents. Indian Journal of Cryogenics, 2004; 32,576-582.
  10. Majumder GC, Kundu CN, Das K, Chakrabarty J, Dutta P, Bhattacharyya D, Ghosh A. Effect of various reagents on cryopreservation of goat cauda epididymal spermatozoa using a chemically-defined model system. In Proceedings of the National Seminar and Conference on Cryogenics and Its Frontier Applications, 2004; pp.113-117.
  11. Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A. Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J Biol Chem. 2003, 7;278(6):3897-902.
  12. Sathyanarayana P, Barthwal MK, Kundu CN, Lane ME, Bergmann A, Tzivion G, Rana A. Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3. Mol Cell. 2002, 10(6):1527-33.
  13. Kundu CN, Chakrabarty J, Dutta P, Bhattacharyya D, Ghosh A, Majumder GC. Effect of dextrans on cryopreservation of goat cauda epididymal spermatozoa using a chemically defined medium. Reproduction. 2002,123(6):907-13.
  14. Kundu CN, Das K, Majumder GC. Effect of amino acids on goat cauda epididymal sperm cryopreservation using a chemically defined model system. Cryobiology. 2001, 42(1):21-7
  15. Kundu CN, Chakraborty J, Dutta P, Bhattacharyya D, Ghosh A, Majumder GC. Development of a simple sperm cryopreservation model using a chemically defined medium and goat cauda epididymal spermatozoa. Cryobiology. 2000, 40(2):117-25.
  16. Kundu CN, Chakraborty J, Dutta P, Bhattacharyya D, Ghosh A and Majumder GC A novel epididymal sperm cryopreservation model for analyzing the cryoprotecting potential of various reagents. In ‘Proceedings of Eighteenth International Cryogenic Engineering Conference (ICEC-18)’, 2000 ; Mumbai, India,

BOOK CHAPTER:

  1. Kundu CN, Mohapatra P, Preet R, Das D, Satapathy SR. “Anticancer Drugs Designed by Mother Nature: An Old Lock Needs a New Key.” Advances in Biochemistry & Biotechnology Volume 2 Ed. Biplab Sarkar and Chiranjib Chakraborty. New Delhi: Daya Publishing House, 2014. 99-120.
  2. Kundu CN, Majumder GC, Preet R. (2010), Cryopreservation of Spermatozoa. Recent Biotechnological advancement in gamete preservation technology, Chapter 15, page- 277-302, IGI global publication, USA.
  3. Saha S., Das K., Banerjee S., Nath D., Maiti A., Barua M., Kundu CN., Mandal M., Chakrabarty J., Jaiswal B. S.,Bhattacharyya D., Chattopadhyay D., Dungdung S. R., Majumder G. C. (2009): Biochemical Parameters of SpermFlagellar Motility Initiation and Regulation. Advanced Medicare (Ed. R. Sen), B. I. Publication Pvt. Ltd, New Delhi

PATENT:

  • N-Fused Aminoimidazoles as Novel Topoisomerase IIα-Targeting Anticancer Agents.  Guchhait SK, Kundu CN, Banerjee UC, Baviskar A,  Madaan C,  Agarwal A,  Preet R, Mohapatra P, (Indian Patent Pending, Appl # 91/DEL/2011).