Dr. Dindyal Mandal
Associate Professor
Ph. D., National Chemical Laboratory, Pune, India
M.Sc. University of Burdwan, India


Email: [email protected]

Post-Doctoral Training

  • Associate Professor, School of Biotechnology, KIIT, Bhubaneswar, Odisha, India, 2011- Present
  • Research Associate, College of Pharmacy, University of Rhode Island, Kingston, RI, USA, 2008-2011
  • Postdoctoral Research Fellow, Department of Pediatrics, UT M. D. Anderson Cancer Center, Houston, TX, USA, 2006-2008
  • Research Fellow, Department of orthopedics, Mayo Clinic, Rochester, MN, USA, 2005-2006
  • Researcher, Department of chemistry and biochemistry, Southern Illinois University, Carbondale, IL, USA, 2004-2005

Research Interest

  • Nanobiotechnology
  • Peptide self-assembly
  • Drug delivery
  • Biotransformation

Awards/Honors

  • CSIR Fellowship (Govt. of India): 1998 – 2003
  • Best oral presentation award at International Conference (IPCAT-2) on Catalysis at NCL, Pune, India, Jan 2001
  • Best paper award by NCL Research Foundation, Pune (2002) for the paper entitled ‘Enzyme mediated extracellular synthesis of CdS Nanoparticles by the Fungus, Fusarium oxysporum,. J. Am. Chem. Soc. 124: 12108-12109, 2002’

Patent

  • G. Sarkar, M. E. Bolander, D. Mandal, E. Mahlum, M. J. Yaszemski. Transport of biologically active molecules into a cell, mitochondrion, or nucleus. US pat application no 12/354,142 (2008)
  • P. Mukherjee, D. Mandal, A. Ahmad, M. Sastry and R. Kumar. Process for the preparation of metal sulfide nanoparticles. US Pat. 6, 783, 963 (August 31, 2004)
  • D. Mandal, A. Ahmad, M. I. Khan and R. Kumar. Process for preparation of lactone from a cyclic ketone. US Pat. 6, 559, 322 (May 6, 2003)
  • P. Mukherjee, D. Mandal, A. Ahmad, M. Sastry and R. Kumar. Process for the Preparation of a nanosized colloidal metal particle. U.S. Pat. 6, 537, 344 (March 25, 2003)
  • P. Mukherjee, A. Ahmad, D. Mandal, S. Senapati, M. I. Khan, M. Sastry and R. Kumar. Process for immobilized nano-sized metal particles. US pat. 7, 759, 098 (July 20, 2010)

Selected Publications

Full List
  1. S. Jena, R. K. Singh, B. Panigrahi, M. Suar, D. Mandal*. Photo-bioreduction of Ag+ ions towards the generation of multifunctional silver nanoparticles: Mechanistic perspective and therapeutic potential. J. Photochem. Photobiol. B: Biology  (IF: 3.0) (In press)
  2. D. Mandal*, A. N. Shirazi, K. Parang*. Self assembly of peptides to nanostructures. (Review) Org. Biomol. Chem. 12, 3544-3561, 2014 (IF: 3.5)
  3. D. Mandal*, A. N. Shirazi, R. Tiwari, A. Banerjee, A. Yadav, K. Parang*. Self-Assembled Surfactant Cyclic Peptide Nanostructures as Stabilizing Agents. Soft Matter  9, 9465-9475, 2013  (IF= 4.3)
  4. D. Mandal, A. Shirazi, K. Parang. Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters. Angew. Chem., Int. Ed. 50 (41), 9633, 2011 (IF=13.7)
  5. A. Ahmad, P. Mukherjee, D. Mandal, S. Senapati, M. I. Khan, R. Kumar and M. Sastry. Enzyme mediated Extracellular synthesis of CdS nanoparticles by the fungus Fusarium oxysporum. J. Am. Chem. Soc. 124, 12108, 2002 (IF=10.6)

Book Chapter

  • Deendayal Mandal. Intracellular delivery of gold nanoparticles: Application in nanomedicine. In: Biomaterials Developments and Applications, pp 435-451, 2010 (ISBN: 978-1-60876-476-1 ), Nova Publishers, NY, USA.

Fabrication of novel biomaterials through peptide self-assembly: Molecular self-assembly using peptides have recently attracted much attention for its use in the design and fabrication of nanostructures for the development of advanced materials. The self-assembly of biomolecular building blocks (e.g., peptides) plays a key role in the discovery of new generation materials for potential applications in nanotechnology and medical sciences such as regenerative medicine and drug delivery systems. Broad objective in this area is to design new biomaterials via self-assembly approach and explore their applications in drug delivery (e.g., small molecule, oligonucleotides, siRNA) and tissue engineering.

Biomineralization: Most traditional methods to synthesize nanoscale inorganic materials require harsh conditions and often produce toxic byproducts. So, there is a need to develop new biomineralization processes using biomimetic approaches to design and synthesize well-defined functional materials under mild, eco-friendly conditions. Long term goal is to find new biomolecules for the synthesis and assembly of nanostructured inorganic materials.

Current Project

  1. ‘Self assembled peptide nanostructures for siRNA delivery’ - sponsored by Department of Biotechnology (DBT), Govt. of India
  2. ‘Peptide-generated metal nanoparticles and their potential biomedical applications’ – sponsored by Department of Science and Technology (DST)-Nanomission, Govt. of India
  3. ‘Synthesis of peptide stabilized quantum dots for imaging applications’ – sponsored by BRNS, Department of Atomic Energy (DAE), Govt. of India

Collaborators

  • Prof. Keykavous Parang, Chapman University, CA, USA
  • Prof. Gobinda Sarkar, Mayo Clinic, MN, USA
  • Dr. Absar Ahmad, NCL, Pune, India

Lab Members

  • Mr. Rohit Kumar Singh, JRF
  • Mr. Bijayananda Panigrahi, SRF
  • Mr. Sourav Mishra, JRF

Research Articles

  1. S. Jena, R. K. Singh, B. Panigrahi, M. Suar, D. Mandal*. Photo-bioreduction of Ag+ ions towards the generation of multifunctional silver nanoparticles: Mechanistic perspective and therapeutic potential. J. Photochem. Photobiol. B: Biology  (IF: 3.0) (In press)
  2. A. N. Shirazi, N. S. El-Sayed, D. Mandal, R. K. Tiwari, K. Tavakoli, M. Etesham, K. Parang. Cysteine and arginine-rich peptides as molecular carriers. Bioorg. Med. Chem. Lett. 26 (2), 656-61, 2016.
  3. T. Akbarzadeh,  A. Rafinejad , A. Fallah-Tafti , R. Tiwari , A. Nasrolahi Shirazi , D. Mandal, K. Parang , A. Foroumadi . Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as src kinase inhibitors. J of Sciences Islamic Republic of Iran 26, 321-325, 2015
  4. S. Jena, B. Das, R. Bosu, M. Suar, D. Mandal*. Bacteria Generated Antibacterial Gold Nanoparticles and Potential Mechanistic Insight. J. of Cluster Science 26 (5), 1707-1721, 2015 (IF: 1.3)
  5. A. N. Shirazi, K. L. Paquin, N. G. Howlett, D. Mandal, K. Parang. Cyclic peptide capped gold nanoparticles for enhanced siRNA delivery. Molecules 19, 13319-13331, 2014 (IF: 2.6)
  6. D. Mandal*, A. N. Shirazi, K. Parang*. Self assembly of peptides to nanostructures. (Review) Org. Biomol. Chem. 12, 3544-3561, 2014 (IF: 3.5)
  7. D. Mandal*, A. N. Shirazi, R. Tiwari, A. Banerjee, A. Yadav, K. Parang*. Self-Assembled Surfactant Cyclic Peptide Nanostructures as Stabilizing Agents. Soft Matter  9, 9465-9475, 2013  (IF= 4.3, citation =1)
  8. A. N.  Shirazi,   R. Tiwari, D. Oh, B. Sullivan, K. McCaffrey, D.  Mandal, K. Parang. Surface Decorated Gold Nanoparticles by Linear and Cyclic Peptides as Molecular Transporters. Mol. Pharm. 10 (8), 3137–3151, 2013  (IF= 4.5, citation=0)
  9. A. N.  Shirazi, D.  Mandal, R. Tiwari, L. Guo, W. Lu, K. Parang. Cyclic Peptide-Capped Gold Nanoparticles as Drug Delivery Systems. Mol. Pharm. 10(2), 500-11, 2013 (IF=4.5, citation=4)
  10. A.  N. Shirazi,  R. K. Tiwari, A. Brown, D. Mandal, G. Sun, K. Parang. Cyclic Peptides Containing Tryptophan and Arginine as Src Kinase Inhibitors. Bioorg. Med. Chem. Lett.  23(11), 3230-4, 2013 (IF=2.3, citation=2)
  11. H. K. Agarwal, B. S. Chhikara, S. Bhavaraju, D. Mandal, G. Doncel, K. Parang. Emtricitabine Prodrugs with Improved Anti-HIV Activity and Cellular Uptake. Mol. Pharm. 10(2), 467-76, 2013 (IF=4.5, citation=3)
  12. A.N. Shirazi, R. Tiwari, B. Chhikara, D.  Mandal,   K. Parang. Design and Evaluation of Cell-Penetrating Peptide-Doxorubicin Conjugates as Prodrugs. Mol. Pharm. 10(2), 488-99, 2013 (IF=4.5, citation=5)
  13. B. S. Chhikara, D. Mandal, K. Parang. Synthesis, Anticancer Activities, and Cellular Uptake Studies of Lipophilic Derivatives of Doxorubicin Succinate. J. Med. Chem. 55, 1500, 2012 (IF= 5.6, citation=6)
  14. R. K. Sharma, S. Singh, R. Tiwari, D. Mandal, C. E. Olsen, V. S. Parmar, K. Parang, Prasad AK. O-Aryl α,β-d-ribofuranosides: synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity. Bioorg Med Chem. 20(23), 6821, 2012 (IF=2.9, citation=1)
  15. A. Rafinejad, A. Fallah-Tafti, R. Tiwari, A. N. Shirazi, D. Mandal, A. Shafiee, K. Parang, Alireza Foroumadi, Tahmineh Akbarzadeh. 4-Aryl-4H-naphthopyrans derivatives: One-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities.  DARU Journal of Pharmaceutical Sciences 20,100, 2012 (IF=0.7, citation=3)
  16. D. Mandal, A. Shirazi, K. Parang. Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters. Angew. Chem., Int. Ed. 50 (41), 9633, 2011 (IF=13.7, citation=12)
  17. H. K. Agarwal, K. A. Loethen, D. Mandal, G. F Doncel, K. Parang.  Synthesis and biological evaluation of Fatty Acyl Ester Derivatives of 2',3'-Didehydro-2',3'-Dideoxythymidine.   Bioorg. Med. Chem. Lett. 21, 1917, 2011 (IF=2.3, citation=6)
  18. B. S. Chhikara, D. Mandal, K. Parang. Fatty-Acyl Amide Derivatives of Doxorubicin: Synthesis and In Vitro Anticancer Activities. Eur. J. Med. Chem. 46(6), 2037, 2011(IF=3.4, citation=11)
  19. A. Gupta, D. Mandal, Y. Ahmadibeni, K. Parang, G. Bothun. Hydrophobicity Drives the Non-specific Cellular Uptake of Short Cationic Peptide Ligands. Eur. Biophysical J. 40(6), 727, 2011(IF=2.2, citation=4)
  20.  A. Fallah-Tafti, R. Tiwari, A. N. Shirazi, T. Akbarzadeh, D. Mandal, A. Shafiee, K. Parang, A. Foroumadia. 4-Aryl-4H-Chromene-3-Carbonitrile Derivatives: Evaluation of Src Kinase Inhibitory and Anticancer Activities. Med. Chem. 7 (5), 466, 2011 (Citation=7)
  21. A. Kumar, I. Ahmad, B. S. Chhikara, R. Tiwari, D. Mandal, K. Parang. Synthesis of 3-Phenylpyrazolopyrimidine-1,2,3-Triazole Conjugates and Evaluation of their Src Kinase Inhibitory and Anticancer Activities. Bioorg. Med. Chem. Lett. 21, 1342, 2011 (IF=2.3, citation=18)
  22. D.  Kumar, V. Buchi Reddy, A. Kumar, D. Mandal, R. Tiwari, and K. Parang. Click chemistry inspired one-pot synthesis of novel 1, 2, 3-triazoles and their Src kinase inhibitory activity. Bioorg. Med. Chem. Lett. 21, 449, 2011. (IF=2.3, citation=17)
  23. B. S. Chhikara, D. Mandal, K. Parang. Synthesis and evaluation of fatty acyl esters derivatives of cytarabine as anti-leukemia agents.  Eur J Med Chem 45, 4601, 2010(IF=3.4, citation=6)
  24. D. Sharma, R. K. Sharma, S. Bhatia, R. Tiwari, D Mandal, J. Lehmann, K. Parang, C.E. Olsen, V. S. Parmar, A. K. Prasad. Synthesis, Src kinase inhibitory and anticancer activities of 1-substituted 3 (N-alkyl-N-phenylamino) propan-2-ols. Biochimie 92, 1164, 2010. (IF=3.1, citation=8)
  25. Y. Wang, D. Mandal,   S. Wang,   E. Kleinerman,   R. Pollock,   D. Lev, A. Hayes-Jordan.  Platelet Derived Growth Factor Receptor Beta Inhibition Increases Tumor Necrosis Factor Related Apoptosis Inducing Ligand sensitivity: Imatinib, TRAIL dual Therapy. Cancer 116, 3892, 2010(IF=5.2, citation=8)
  26. Y. X. Wang, D. Mandal, S. Wang, D. Hughes, R. E. Pollock, D. Lev, E. Kleinerman, A. Hayes-Jordan. Inhibiting Platelet Derived Growth Factor Beta (PDGFR-B) decreases Ewing’s Sarcoma Growth and Metastasis in a Novel Orthotopic Human Xenograft Model. In Vivo 23, 903, 2009(IF=1.2, citation=4)
  27. D. Mandal*, A. Maran, M. J. Yaszemski, M E Bolander and G Sarkar. Cellular uptake of gold nanoparticles directly cross-linked with carrier peptides by Osteosarcoma cells. J. Mater. Sci: Mater. Med. 20, 347, 2009 (IF=2.1, citation=23)
  28. Y. Wang, D. Mandal, Andrea Hayes-Jordan. Platelet derived growth factor beta (PDGF-B), is required for pericyte requirement and angiogenesis in Fibrosarcoma.   J. Am. College of Surgeons 205, 3, 2007
  29. D. Mandal, A. Srivastava, E. Mahlum, D. Desai, A. Maran, M. Yaszemski, S. M. Jalal, S. Gitelis, F. Bertoni, T. Damron, R. Irwin, M. O. Connor, H. Schwartz, M. E. Bolander and G. Sarkar. Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma. Gene 386, 131, 2007 (IF=2.1, citation=16)
  30. E. Mahlum, D. Mandal, C. Halder, A. Maran, M. J. Yaszemski, R. B. Jenkins, M. E. Bolander, G. Sarkar. Engineering a non-carrier to a carrier peptide for non-covalently delivering biologically active proteins into human cells. Anal Biochem 365, 215, 2007(IF=2.5, citation=5)
  31. D. Mandal*, M. E. Bolander, D. Mukhopadhyay, G. Sarkar and P. Mukherjee. The use of microorganisms for synthesis of metal nanoparticles and their application (Minireview). Applied Microbiol and Biotechnol 69, 485, 2006 (IF=3.6, citation=370)
  32. H. M. Gardimalla, D. Mandal, P. Stevens, M. Yen, and Y. Gao. Superparamagnetic nanoparticle supported enzymatic resolution of racemic carboxylates. Chem. Commun. 4432, 2005(IF=6.1, citation=54)
  33. D. Mandal, A. Ahmad, M. I. Khan and R. Kumar. Enantioselective bioreduction of acetophenone and its analogous by the fungus Trichothecium sp.      J. Mol. Catal. B: Enzym. 27, 61, 2004 (IF=2.8, citation=40)
  34. A. Ahmad, P. Mukherjee, S. Senapati, D. Mandal, M. I. Khan, R. Kumar and Murali Sastry. Extracellular biosynthesis of silver nanoparticles using the fungus Fusarium oxysporum. Coll. and Surf. B: Biointerfaces 28, 313, 2003 (IF=3.5, citation=527)
  35. P. Mukherjee, S. Senapati, D. Mandal, A. Ahmad, M. I. Khan, R. Kumar and M. Sastry. Extra-cellular Synthesis of Gold Nanoparticles by the Fungus, Fusarium oxysporum. ChemBioChem. 3, 461, 2002(IF=3.9, citation=295)
  36. D. Mandal, A. Ahmad, M. I. Khan and R. Kumar. Biocatalytic transformation of cyclohexanone by Fusarium sp.  J. Mol. Catal. A: Chemical 181, 237, 2002 (IF=3.1, citation=11)
  37. A. Ahmad, P. Mukherjee, D. Mandal, S. Senapati, M. I. Khan, R. Kumar and M. Sastry. Enzyme mediated Extracellular synthesis of CdS nanoparticles by the fungus Fusarium oxysporum. J. Am. Chem. Soc. 124, 12108, 2002(IF=10.6, citation=184)
  38. P. Mukherjee, A.  Ahmad, D. Mandal, S. Senapati, S.  R. Sainkar, M.  I. Khan, R. Parishcha, P. V. Ajayakumar, M. Alam, R.  Kumar and M.  Sastry. Fungus mediated synthesis of silver nanoparticle and their immobilization in the mycelial matrix: A novel biological approach to nanoparticle synthesis. Nano Lett 1, 515, 2001 (IF=13.0, citation= 434)
  39. P. Mukherjee, A. Ahmad, D. Mandal, S. Senapati, S. R. Sainkar, M. I. Khan, R. Ramani, R. Parishcha, P. V. Ajayakumar, M. Alam, R. Kumar and M. Sastry, Bioreduction of AuCl4- ions by the fungus, Verticillium and surface trapping of gold   nanoparticle thus formed. Angew. Chem. Int. Ed. Engl.  40, 3585, 2001(IF=13.7, citation=384)
  40.  P. Mukherjee, S. Laha, D. Mandal, and R. Kumar.   Organo-functionalized surface modified MCM-41 type mesoporous materials having various organic functional groups. Stud. Surf. Sci. Catal. 129, 283, 2000 (Citation=11)

(*) indicates corresponding author

Research Work highlighted in

  1. Current Science 2002, 82, 1419
  2. News India (Nature publishing group, India, Oct 2001)
  3. Chemical & Engineering News (ACS publication), 2001, 27
  4. Nanozone 2002 (Nature publishing)
  5. Environmental Science & Technology (ACS publication), 2001, 35, 479A-480A
  6. Science News, July, 2003 (published by Scientific Americana)
  7. Science-Business eXchange4, doi:10.1038/scibx.2011.1100 (6th Oct, 2011, Nature publishing)

Book Chapter

  • D. Mandal. Intracellular delivery of gold nanoparticles: Application in nanomedicine. In: Biomaterials Developments and Applications, pp 435-451, 2010 (ISBN: 978-1-60876-476-1), Nova Publishers, NY, USA.

Patents

  1. G. Sarkar, M. E. Bolander, D. Mandal, E. Mahlum, M. J. Yaszemski. Transport of biologically active molecules into a cell, mitochondrion, or nucleus. US pat  application no 12/354,142 (2008)
  2. P. Mukherjee, D. Mandal, A. Ahmad, M. Sastry and R. Kumar. Process for the preparation of metal sulfide nanoparticles. US Pat. 6, 783, 963 (2004)
  3. D. Mandal, A. Ahmad, M. I. Khan and R. Kumar. Process for preparation of lactone from a cyclic ketone.   US Pat.  6, 559, 322 (2003)
  4. P. Mukherjee, D. Mandal, A. Ahmad, M. Sastry and R. Kumar. Process for the Preparation of a nanosized colloidal metal particle.  U.S.  Pat.  6, 537, 344 (2003)
  5. P. Mukherjee, A. Ahmad, D. Mandal, S. Senapati, M. I. Khan, M. Sastry and R. Kumar.  Process for the preparation of immobilized nanoparticles.   US pat. 7, 759, 098 (2010)