Dr. Naresh Chandra Bal
Associate Professor

Research Experience

Assistant Professor (Research), SBP Medical Discovery Institute, Orlando FL USA 2015-2016
Post-Doctoral Researcher; The Ohio State University, Columbus, USA. 2007 - 2015
Researcher, University of Saarland, Saarbrucken, Germany 2007 - 2007

Research Interest

Cases of obesity, diabetes and associated metabolic disorders are increasing rapidly all over the world. A positive energy balance over a period of time is considered as one of the major factors initiating these conditions. The energy cost of maintaining a constant body temperature (thermoregulation) is a dynamic component that greatly influence the whole body metabolism, thereby energy balance. In order to counter obesity and other metabolic disorders, mechanisms contributing to thermoregulation has to be carefully defined. Skeletal muscle and brown fat are two major sites in the mammalian body that are recruited during cold adaptation, a condition that require heat production from the inside of the body. The mitochondrial metabolism is very intricately intertwined with the thermogenic status in both the tissues. The mechanisms that operate under thermoneutral and mild cold conditions in muscle and brown fat can have significant implication for obesity and metabolic syndrome including diabetes.

My laboratory will be working towards delineating the role of the above mechanisms at different stages of diabetes. Towards this we would try to define the energy status of these tissues in obese, pre-diabetic and/or diabetic people in this part of the world. The particular questions that we will try to address are;

  • Defining muscle thermogenic mechanisms in various pathophysiology conditions.
  • Role of muscle thermogenesis in malignant hyperthermia and heat stroke.
  • Muscle thermogenesis in evolution of homeothermy among vertebrates taxa.
  • Importance of muscle Ca2+-handling proteins in physiology and disease.

In addition, we will work towards the discovery of novel therapeutic approaches for cardiac arrhythmia, and obesity.

Awards / Honors

  • Career Development Award (K01) from NIDDK-NIH, USA, 2015.
  • Fellow of Green Earth Research Foundation (FGERF), 2012.
  • Postdoctoral Recognition from The Ohio State University, 2011.
  • American Heart Association Postdoctoral Fellow, 2010.
  • American Physiological Society Physiological Genomics Fellow, 2010.
  • Senior Research Fellowship, CSIR, India, 2004.
  • Junior Research Fellowship, CSIR; Top 20% in India, 2002.

Selected Publications

  1. Sarcolipin: key thermogenic and metabolic regulator in skeletal muscle. Pant M, Bal NC and Periasamy M. (2016) Trends in Endocrinology & Metabolism. Accepted.
  2. Increased reliance on muscle based thermogenesis upon acute minimization of brown adipose tissue function. (2016) Bal NC, Maurya SK, Singh S, Wehrens XH, and Periasamy M. Journal of Biological Chemistry. 291(33): 17247-57.
  3. Uncoupling Protein 1 and Sarcolipin are required to maintain optimal thermogenesis and loss of both systems compromises survival of mice under cold stress. Rowland LA, Bal NC, Kozak LP and Periasamy M. (2015) Journal of Biological Chemistry. 290(19): 12282-9.
  4. Sarcolipin is a key determinant of basal metabolic rate and its overexpression enhances energy expenditure and resistance against diet induced obesity. Maurya SK, Bal NC, Saporiwala DH, Pant M, Rowland LA, Shaikh SA and Periasamy M. (2015) Journal of Biological Chemistry. 290(17): 10840-9.
  5. Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Bal NC, Maurya SK, Saporiwala DH, Sahoo SK, Gupta SC, Shaikh SA, Pant M, Rowland LA, Bombardier E, Goonasekera SA, Tupling AR, Molkentin JD and Periasamy M. (2012) Nature Medicine. 18(10):1575-9.
  6. Probing cationic selectivity of Cardiac Calsequestrin and its CPVT mutants. Bal NC*, Jena N, Saporiwala D, Balaraju T, Shaikh S, Bal C, Sharon A, Gyorke S and Periasamy M. (2011) Biochemical Journal. 435(2): 391-399.

Collaborators

  1. Professor Muthu Periasamy, University of Florida, Orlando, FL USA
  2. Professor Ouliana Ziouzenkova, The Ohio State University, Columbus, OH USA
  3. Marta Gaburjakova, Slovak Academy of Sciences, Bratislava, Slovak Republic
  4. Ashoke Sharon, Birla Institute of Technology, Ranchi, Jharkhand, India
  5. Katsu Funai, East Carolina Diabetes and Obesity Institute, Greenville, NC USA