Dr. Ratna Kumari
DBT Bio-Care Scientist
Ph. D. National Centre for Cell Science, Pune


Email : [email protected]

Post-Doctoral Training

University of California Davis Medical Centre, Sacramento, California.

Biosketch

Ratna Kumari has received her Ph. D. in Cancer Biology from the National Centre for Cell Science Pune. After completing her doctoral studies, she moved to the University of California Davis Medical Centre, Sacramento, California for her post-doctoral research.  There she worked on the oncogene Leukemia/lymphoma-related factor (LRF) and elucidated its role in chondrogenesis as well as in chondrosarcoma before joining the KSBT.

Group name/Research Interest

Interaction among cell signaling pathways and therapeutic importance of these interactions for cancer treatment. Wnt and Hedgehog signaling pathways are important developmental signaling pathways and at present we are working on the interaction of these pathways in Hepatocellular carcinoma.

Research Description

Hepatocellular carcinoma (HCC) is the fifth most frequently diagnosed cancer and is the third leading cause of cancer related mortality worldwide. HCC is particularly refractory to the available chemotherapeutic drugs. The treatments currently available to prolong survival are surgical resection/ablation and liver transplantation, which is effective only in small group of patients. To develop more effective therapeutics, we need to dissect the underlying molecular pathways that derive HCC development. Wnt and Hedgehog (Hh) signaling pathways play key roles in embryogenesis, tissue patterning, morphogenesis, stem cell maintenance, and tumorigenesis. We intend to design both mechanistic and translational studies, for the investigation of interaction between these two pathways in HCC. This project has potential to investigate the role of common molecules found in Wnt and Hh signaling pathways in HCC and will improve our fundamental knowledge about the role of developmental signaling pathways in hepatocarcinogenesis.

Collaborators

Manoj Kumar Bhat, Ph.D. Scientist 'G' , Laboratory No. 6. National Centre for Cell Science NCCS Complex, Pune University Campus Ganeshkhind, PUNE

Selected Publications

Full List
  1.  Jasper HN Yik, Huan Li, Chitrangada Acharya, Ratna Kumari, Fernando Fierro, Dominik R Haudenschild, Jan Nolta, Paul E DiCesare (2013) The Oncogene LRF Stimulates Proliferation of Mesenchymal Stem Cells and Inhibits Their Chondrogenic Differentiation. Cartilage 10/2013; 4(4):329. DOI: 10.1177/1947603513497570
  2. Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR. Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines. Arthritis Rheumatol. 2014 Jun;66(6):1537-46. doi: 10.1002/art.38378.
  3. Meena AS, Sharma A, Kumari R, Mohammad N, Singh SV, Bhat MK. Inherent and acquired resistance to paclitaxel in hepatocellular carcinoma: molecular events involved. PLoS One. 2013 Apr 16;8(4):e61524. doi: 10.1371/journal.pone.0061524. Print 2013.
  4. Kumari R, Li H, Haudenschild DR, Fierro F, Carlson CS, Overn P, Gupta L, Gupta K, Nolta J, Yik JH, Di Cesare PE. The oncogene LRF is a survival factor in chondrosarcoma and contributes to tumor malignancy and drug resistance. Carcinogenesis. 2012 Nov;33(11):2076-83. doi: 10.1093/carcin/bgs254. Epub 2012 Jul 30.
  5. Kumari R, Ajay AK, Sharma A, Bhat MK. Mitomycin C induces bystander killing in homogeneous and heterogeneous cellular models of hepatocellular carcinoma. Mol Cancer 2009. 8:87.

Collaborators

  • Manoj Kumar Bhat, Ph.D. Scientist 'G' , Laboratory No. 6. National Centre for Cell Science NCCS Complex, Pune University Campus Ganeshkhind, PUNE

Lab Members

Anandita Tripathy
JRF

Publications

  1.  Jasper HN Yik, Huan Li, Chitrangada Acharya, Ratna Kumari, Fernando Fierro, Dominik R Haudenschild, Jan Nolta, Paul E DiCesare (2013) The Oncogene LRF Stimulates Proliferation of Mesenchymal Stem Cells and Inhibits Their Chondrogenic Differentiation. Cartilage 10/2013; 4(4):329. DOI: 10.1177/1947603513497570
  2. Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR. Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines. Arthritis Rheumatol. 2014 Jun;66(6):1537-46. doi: 10.1002/art.38378.
  3. Meena AS, Sharma A, Kumari R, Mohammad N, Singh SV, Bhat MK. Inherent and acquired resistance to paclitaxel in hepatocellular carcinoma: molecular events involved. PLoS One. 2013 Apr 16;8(4):e61524. doi: 10.1371/journal.pone.0061524. Print 2013.
  4. Kumari R, Li H, Haudenschild DR, Fierro F, Carlson CS, Overn P, Gupta L, Gupta K, Nolta J, Yik JH, Di Cesare PE. The oncogene LRF is a survival factor in chondrosarcoma and contributes to tumor malignancy and drug resistance. Carcinogenesis. 2012 Nov;33(11):2076-83. doi: 10.1093/carcin/bgs254. Epub 2012 Jul 30.
  5. Kumari R, Ajay AK, Sharma A, Bhat MK. Mitomycin C induces bystander killing in homogeneous and heterogeneous cellular models of hepatocellular carcinoma. Mol Cancer 2009. 8:87.
  6. Gholap AR, Toti KS, Shirazi F, Kumari R, Bhat MK, Deshpande MV, Srinivasan KV. Synthesis and evaluation of antifungal properties of a series of the novel 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and its analogues. Bioorg Med Chem 2007.
  7. Chhipa RR, Kumari R, Upadhyay AK, Bhat MK. Abrogation of p53 by its antisense in   MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promoting cell proliferation. Exp Cell Res 2007; 313:3945-3958.
  8. Ajay AK, Upadhyay AK, Singh S, Vijayakumar MV, Kumari R, Pandey V, Boppana R, Bhat MK (2010). Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression. Mol Cancer 9:204.