Dr. Sasmita Nayak
Assistant Professor, Adjunct Assistant Professor, KIIT (KIMS)
Ph.D Rensselaer Polytechnic Institute, Troy, NY, USA, 2012
M.B.B.S 1995 S.C.B Medical College Hospital, Cuttack, Orissa, India


Email: [email protected]

Professional Experiences

  • Research Fellow, Department of Biology, Rensselaer Polytechnic Institute, Troy, NY, USA (2011-2012).
  • Research Assistant, Department of Biology, Rensselaer Polytechnic Institute, Troy, NY, USA (2008-2010).
  • Research Assistant, Center for Immunology and Microbial Diseases, Albany medical Center, Albany, NY, USA (2006-2008).
  • Visiting Physician, Department of Neurology, Albany Medical Center, Albany, NY, USA (2004-2005).
  • Visiting Physician, Department of Pediatrics, Ellis Hospital, Schenectady, NY, USA (2000-2003).
  • Internship, S.C.B Medical College Hospital, Orissa, India (1995-1996).

Awards/Honours

  • Graduate research fellowship (2011-2012) Rensselaer Polytechnic Institute, Troy, NY, USA

Current Research Activity

Tuberculosis (TB) stands out as the most widespread infectious disease in the world and is a major health problem in India. About 2 billion of people are currently infected with Mycobacterium tuberculosis (Mtb) worldwide leading to about 3 million death every year. Since multi drug resistance TB is emerging as a new global health hazard, intein-splicing inhibitors targeting the essential proteins in mycobacteria would provide a novel platform for treating TB. Inteins are mobile genetic elements or “intervening sequences” that interrupt the coding sequence of a gene and are found in all the three domains of life. Our current work focuses primarily on providing the precise understanding of the mechanism of splicing regulation in Mtb SufB intein for development of novel anti- tubercular drug(s).

Selected Publications

Full List
  1. Natalya I. Topilina, Cathleen M. Green, Pradeepa Jayachandran, Danielle S. Kelley, Matthew J. Stanger, Carol Lyn Piazza, Sasmita Nayak, and Marlene Belfort. SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses. PNAS August 18, 2015; 112 (33) 10348-10353
  2. Y. M. Huang, S. Nayak and C. Bystroff, “Quantitative in vivo solubility and reconstitution of truncated circular permutants of green fluorescent protein”, Protein Science 20, 1775 (2011).

Group name/Research Interest: Infection Biology Group

Tuberculosis (TB) stands out as the most widespread infectious disease in the world and is a major health problem in India. About 2 billion of people are currently infected with Mycobacterium tuberculosis (Mtb)worldwide leading to about 3 million death every year. Since multi drug resistance TB is emerging as a new global health hazard, intein-splicing inhibitors targeting the essential proteins in mycobacteria would provide a novel platform for treating TB. Inteins are mobile genetic elements or “intervening sequences” that interrupt the coding sequence of a gene and are found in all the three domains of life. Our current work focuses primarily on providing the precise understanding of the mechanism of splicing regulation in Mtb SufB intein for development of novel anti- tubercular drug(s).

Indo-US Science and Technology Forum (IUSSTF): 2014 - 2016

Consultancy Project ongoing
1-To test the antibacterial activities of graphene coated metal surfaces on different bacteria (V. Cholerea, S. pyogenes, S. aureus, P. aeruginosa, E. coli, S. enteritidis etc.) using the methods developed against BL21 (DE3) E. coli strain.
Funded by Tata Steel Jamshedpur (2016-2019)
Sponsored Projects ongoing
1- Elemental Mapping and its use in regulation of mycobacterial SufB splicing by metals and its possible use as metal sensor.
Funded by UGC-DAE CSR, Kolkata centre (2015-2018)
2- Indo-US Joint Center on Nanostructure Genomics: Designing Functionality of 2-Dimensional Nanostructures and Nano-Bio Interfaces
Funded by Indo-US Science and Technology Forum (IUSSTF) (2014-2017)
Completed projects
1- Testing anti bacterial activities of graphene on various surfaces (steel, iron, nickel, zinc)
Funded by Tata Steel Jamshedpur (2014-2015)

Internationally:

  1. Dr. Marlene Belfort, PhD
    Distinguished Professor
    Member, National Academy of Sciences
    Biological Sciences
    University at Albany, State University of New York, USA
  2. Dr. Kathleen A. McDonough, PhD
    Deputy Director, Wadsworth Center, Division of Infectious Disease, USA
    Research Scientist, Wadsworth Center, Microbial Genetics
, USA
    Associate Professor, School of Public Health, Biomedical Sciences, USA
    Faculty Member, Wadsworth School of Laboratory Sciences, USA

Nationally:

  1. Dr. V. R. Pedireddi, PhD
    Professor
    Dean, Continuing Education Programme (CEP)
    School of Basic Sciences, Indian Institute of Technology, Bhubaneswar, India
  2. Dr. Anasuya Roychowdhury, PhD
    Assistant Professor
    School of Basic Sciences, Indian Institute of Technology, Bhubaneswar, India
  3. Dr. Tapan K. Rout, PhD
    Research and Development, TATA Steel Limited, Jamshedpur, India

Current:

PhD student
Ms. Sunita Panda (03/2014- current)
Project Fellows
Ms. Ananya Nanda
Mr. Pawan Prabhakar

Past:

MS students
Ms. Jayeeta Kar (graduation- 11/2014)
Ms Saswati Pani (graduation- 11/2014)
Ms Swatishree Pattjoshi (graduation- 11/2015)
Ms Ananya Nanda (graduation- 11/2016)
Mr Anonyo Jyoti Mishra (graduation- 11/2016)

  • Natalya I. Topilina, Cathleen M. Green, Pradeepa Jayachandran, Danielle S. Kelley, Matthew J. Stanger, Carol Lyn Piazza, Sasmita Nayak, and Marlene Belfort. SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses. PNAS August 18, 2015; 112 (33) 10348-10353
  • Y. M. Huang, S. Nayak and C. Bystroff, “Quantitative in vivo solubility and reconstitution of truncated circular permutants of green fluorescent protein”, Protein Science 20, 1775(2011)