Dr. Tithi Parija
Assistant Professor
Ph. D. Institute of Life Sciences ,Bhubaneswar,Odisha (2003)
M. Sc. PG Dept. of Zoology, Utkal University, Bhubaneswar, Odisha (1996)


Email : [email protected]

Postdoctoral Experience

Dept. of Molecular Oncology, Cancer Institute (WIA), Chennai, India from 2003 to 2005.

Research Interest

Molecular Biology of Oral Cancer

Awards/Honours

  • Senior Research Fellowship awarded by CSIR, India (1999)
  • Received State Young Scientist Award for the Year 2002 from the Dept. of Science & Technology, Govt. of Orissa, India.
  • Post doctoral fellowship awarded by DBT, India in (2003)
  • DBT Bio-CARe award(2012)
  • Life member of Indian Association of Cancer Research

Selected Publications

Full List
  1. Giri RK, Parija T and Das BR, D-limonene Chemoprevention of Hepatocarcinogenesis in AKR mice. Inhabitation of C-jun and C-myc, Oncology Reports, 6, 123-127, 1999.
  2. Sahu GR, Nayak BK, Patnaik S, Parija T and Das BR, Rearrangement of P53 gene with over expressed P53 protein in Primary Cervical Cancer, Oncology Reports, 9, 433-437, 2002.
  3. Parija T & Das BR, Involvement of YYI and its correlation with c-myc in NDEA induced Hepatocarcinogenesis, its prevention by d-limonene, Molecular Biology Reports, 30(1), 41-46, 2003.
  4. Parija T, Shirley S, Uma S, Rajalekshmy KR, Ayyappan S, Rajkumar T, Type 1 (11; 22) (q 24 : q12) translocation is common in Ewing’s Sarcoma/Peripheral Neuro Ectodermal Tumor in South Indian Patients, J.Biosciences, 30(3), 371-376, 2005.
  5. Soumittra N, Meenakumari B, Parija T, Sridevi V, Nancy KN, Swaminathan R, Rajalekshmy KR, Majhi U, Rajkumar T, Molecular genetics analysis of hereditary breast and ovarian cancer patients in India. Hered Cancer Clin Pract., 6; 7(1):13-23, 2009.

Breast cancer is appearing to represent enormous public health problem.  Importance of estrogen in breast cancer development is due to the changes in estrogen signaling and expression of estrogen receptors during breast tumorigenesis and progression. ERα point mutations have not provided much insight into the mechanism of action of ER, because relatively few naturally occurring point mutation have been identified. So the focus of our research is primarily to identify ERα mutation in breast cancer patients with reference to local population. The anti-estrogen tamoxifen is the most commonly used treatment for patients with ER-positive breast cancer. Although many patients benefit from it, tamoxifen resistance is an important clinical problem. The complexity of ER activation and tamoxifen interaction with ER provides several potential mechanisms by which resistance to tamoxifen might evolve.

Project title: Study on Estrogen Receptor alpha (ERα) in breast cancer patients with reference to local population.

Collaborators

  • Dr Ghanshyam Biswas, Executive Chairman, Sparsh Hospital, Bhubaneswar
  • Dr. Sushil K Giri, Director, Acharya Harihar Regional Cancer Centre, Cuttack

Lab Members

Deepa Mandal (JRF)
Email : [email protected]

Publications

  1. Giri RK, Parija T and Das BR, D-limonene Chemoprevention of Hepatocarcinogenesis in AKR mice. Inhabitation of C-jun and C-myc, Oncology Reports, 6, 123-127, 1999.
  2. Sahu GR, Nayak BK, Patnaik S, Parija T and Das BR, Rearrangement of P53 gene with over expressed P53 protein in Primary Cervical Cancer, Oncology Reports, 9, 433-437, 2002.
  3. Parija T & Das BR, Involvement of YYI and its correlation with c-myc in NDEA induced Hepatocarcinogenesis, its prevention by d-limonene, Molecular Biology Reports, 30(1), 41-46, 2003.
  4. Parija T, Shirley S, Uma S, Rajalekshmy KR, Ayyappan S, Rajkumar T, Type 1 (11; 22) (q 24 : q12) translocation is common in Ewing’s Sarcoma/Peripheral Neuro Ectodermal Tumor in South Indian Patients, J.Biosciences, 30(3), 371-376, 2005.
  5. Chistine Weyn, Selma Boulenouar, Vanessa mathys, Julie Vanhoolandt, Aurore Bernis, Veronique Fontaine and RIIP and INCTR Workshop Study Group, Detection of Human papilloma Viruses types 45 and 51 by type specific polymerase chain reaction, Journal of Virological Methods, 146, 405-408, 2007.
  6. Soumittra N, Meenakumari B, Parija T, Sridevi V, Nancy KN, Swaminathan R, Rajalekshmy KR, Majhi U, Rajkumar T, Molecular genetics analysis of hereditary breast and ovarian cancer patients in India. Hered Cancer Clin Pract., 6; 7(1):13-23, 2009.