Dindyal Mandal

Associate Professor

Dr. Mandal has eight years of teaching and twenty years of research experience. He earned his Ph. D (Chemistry) from CSIR-National Chemical Laboratory, Pune, India and got postdoctoral training at several reputed institutes (Mayo clinic, M D Anderson Cancer Center, University of Rhode Island) in USA. Broad objective of his research involves the application of chemistry in solving the biological problem. Major areas of interest include developing peptide based drug delivery systems, exploring peptide based green synthesis of metal nanoparticles and quantum dots and their biomedical applications. He has published more than fifty papers in international journals and filed seven patents.

Profile Links

Email :
[email protected]
Google Scholar :

Social Links

Educational Qualification
Ph. D

Completed projects
  1. ‘Self assembled peptide nanostructures for siRNA delivery’ - sponsored by Department of Biotechnology (DBT), Govt. of India (2015-2019)
  2. ‘Peptide-generated metal nanoparticles and their potential biomedical applications’ – sponsored by Department of Science and Technology (DST)-Nanomission, Govt. of India (2015-2018)
  3. ‘Synthesis of peptide stabilized quantum dots for imaging applications’ – sponsored by BRNS, Department of Atomic Energy (DAE), Govt. of India (2015-2019)

Journals/Conferences :
1. Dindyal Mandal, Sandeep Lohan, Muhammad Imran Sajid, Abdulelah Alhazza, Rakesh Kumar Tiwari , Keykavous Parang , Hamidreza Montazeri Aliabadi. Modified Linear Peptides Effectively Silence STAT-3 in Breast Cancer and Ovarian Cancer Cell lines. Pharmaceutics (2023) Feb 16;15(2):666. doi: 10.3390/pharmaceutics15020666.

2. S. Mishra, B. Panigrahi, R.K. Singh, D. Mandal. Catechol Mediated Synthesis of Monometallic and Bimetallic Nanoparticles and Catalytic Efficiency of Monometallic Nanoparticles. Catalysis Letters, 2022 (https://doi.org/10.1007/s10562-022-04095-z)

3. S Lohan, D Mandal, W Choi, AG Konshina, RK Tiwari, RG Efremov, I. Maslennikov, K. Parang. Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. Journal of Medicinal Chemistry 2022, 65 (1), 665-687

4. Muhammad Imran Sajid, Dindyal Mandal, Nagla Salem El-Sayed,Sandeep Lohan, Jonathan Moreno, Rakesh Kumar Tiwari. Oleyl conjugated Histidine-Arginine cell-penetrating peptides as promising agents for siRNA delivery. Pharmaceutics 2022, 14(4):881 ISSN: 1999-4923, https://doi.org/10.3390/pharmaceutics14040881,

5. David Salehi, Saghar Mozaffari, Khalid Zoghebi, ,Sandeep Lohan, Dindyal Mandal, Rakesh K Tiwari, Keykavous Parang.Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Agents. Cells, 2022, 11(7):1156 doi: 10.3390/cells11071156

6. D. Mandal, E. Mohammad, S. Lohan, P. Mandipoor, D. Baradaran, R. Tiwari, K. Parang, H. Montazeri. Redox responsive disulfide peptides: A new strategy for siRNA delivery. Mol. Pharm. 2022, 19, 5, 1338–1355 (ISSN: 1543-8384) https://doi.org/10.1021/acs.molpharmaceut.1c00879
7. R. G Kerry, P. Mohapatra, A B Jena, B Panigrahi, K C Pradhan, B R Khatua, S Mahari, V Perikala, B Kisan, M D. Lugos, A K Mondru, S K. Sahoo, D Mandal, S Pal, S Majhi, J K Patra.Biosynthesis of Rutin trihydrate loaded silica nanoparticles and investigation of its antioxidant, antidiabetic and cytotoxic potentials. Journal of Inorganic and Organometallic Polymers and Materials. 2022, 32, 2065–2081 ( https://doi.org/10.1007/s10904-022-02269-1)

8. B. Panigrahi, R. Singh, U. Suryakanta, S. Mishra, A. Potnis, A. B. Jena, R. G. Kerry, H. Rajaram, S. K. Ghosh, D. Mandal*. Cyclic peptide nanospheres: A ' 2 in 1' delivery system for targeting nucleus and cytoplasm. Eur J. Pharm. Sci. 106125, 171, 2022.

9. AN SHirazi, MI Sajid, D. Mandal, D Stickley, S Nagasawa, J Long, S Lohan, K Parang, R K Tiwari. Cyclic peptide-gadoliniumnanocomplexes as siRNA delivery tools. Pharmaceuticals 1064, 14, 2021
10. S. Kumar, D. Mandal, S. Mozaffari, S. Ahmed El-Mowafi, R. K. Tiwari*, K. Parang*. Click-Free Synthesis of a Multivalent Tricyclic Peptide as a Molecular Transporter. Pharmaceutics 842, 12, 2020
11. Shirazi AN, Park SE, Rad S, Baloyan L, Mandal D, Sajid MI, Hall R, Lohan S, Zoghebi K, Parang K, Tiwari RK. Cyclic peptide-gadolinium nanoparticles for enhanced intracellular delivery. Pharmaceutics. 12(9):792, 2020
12. R K Singh, S S Behera, K Rani Singh, S Mishra, B. Panigrahi, T R Sahoo, P K Parhi, D. Mandal*. Biosynthesized gold nanoparticles as photocatalysts for selective degradation of cationic dye and their antimicrobial activity. J. Photochem. Photobiol. A: Chemistry 112704, 400, 2020.
13. E. H. M. Mohammed, D. Mandal (Equal contribution), S. Mozaffari, M. Abdel-Hamied Zahran, A. M. Osman, R. K. Tiwari*, K. Parang*. Comparative Molecular Transporter Properties of Cyclic Peptides Containing Tryptophan and Arginine Residues Formed Through Disulfide Cyclization. Molecules 2581, 25(11), 2020
14. B. S. Chhikara, S. Ashraf, S. Mozaffari, N. St. Jeans, D. Mandal, R. K. Tiwari, Z. Ul-Haq and K. Parang. Phenylpyrazalopyrimidines as Tyrosine Kinase Inhibitors. Molecules 2135, 25(9), 2020
15. R. K. Singh, P. Bhol, D. Mandal *, P. S. Mohanty*. Stimuli-Responsive Photoluminescence Soft Hybrid Microgel Particles: Synthesis and Characterizations. J. of Physics: Condensed Matter 2020, 32, 044001, DOI 10.1088/1361-648X/ab4ac5
16. P. P. Rath, S. S. Behera, B. Priyadarshini, S. R. Panda, D. Mandal, T. Sahoo, S. Mishra, T. R. Sahoo, P. K. Parhi. Inflence of Mg doping on ZnO NPs for enhanced adsorption activity of congo red dye. Appl. Surf. Sci. 491, 256-266, 2019
17. S. R. Panda, R. Singh, B. Priyadarshini, P. P. Rath, P. Parhi, T. Sahoo, D. Mandal*, Tapas R. Sahoo*. Nanoceria: A Rare-Earth Nanoparticle as a promising Anti-Cancer Therapeutic Agent in Colon Cancer. Materials science in semiconductor processing 104,104669, 2019
18. B. Panigrahi, S. Mishra, R. Singh, D. Mandal*. Peptide generated anisotropic gold nanoparticles as efficient siRNA vectors. Int. J. Pharmaceutics 563 (2019) 198-207
19. S. S. Behera, Subhendu K. Panda, D. Mandal, P. K. Parhi. Ultrasound and microwave assisted leaching of neodymium from waste magnet using organic solvent. Hydrometallurgy 185, 61-70, 2019
20. R. K. Singh, S. Mishra, B. Panigrahi, B. Das, R. Jayabalan, P. K. Parhi, D. Mandal*. pH triggered green synthesized silver nanoparticles toward selective colorimetric detection of kanamycin and hazardous sulfide ions. J. Mol. Liquids 269, 269-277, 2018
21. B. Panigrahi, R. K. Singh, S. Mishra, D. Mandal*. Cyclic peptide based nanostructures as efficient siRNA carriers. Artificial Cells, Nanomedicine and Biotechnology 46, S763-773, 2018
22. R. K. Singh, S. Mishra, S. Jena, B. Panigrahi, B. Das, R. Jayabalan, P. K. Parhi, D. Mandal*. Rapid colorimetric sensing of Gadolinium by EGCG-derived AgNPs: the development of nanohybrid bioimaging probe. Chem. Commun. 54, 3981-3984, 2018
23. S. Das, S.S. Behera, B.M. Murmu, R.K. Mohapatra, D. Mandal, R. Samantray, P.K. Parhi, G. Senanayake. Extraction of scandium(III) from acidic solutions using organo-phosphoric acid reagents: A comparative study. Separation and Purification Technology 202, 248-258, 2018
24. S. Jena, R. K. Singh, B. Panigrahi, M. Suar, D. Mandal*. Photo-bioreduction of Ag+ ions towards the generation of multifunctional silver nanoparticles: Mechanistic perspective and therapeutic potential. J. Photochem. Photobiol. B: Biology 164, 306-313, 2016
25. A. N. Shirazi, N. S. El-Sayed, D. Mandal, R. K. Tiwari, K. Tavakoli, M. Etesham, K. Parang. Cysteine and arginine-rich peptides as molecular carriers. Bioorg. Med. Chem. Lett. 26 (2), 656-61, 2016
26. T. Akbarzadeh, A. Rafinejad, A. Fallah-Tafti, R. Tiwari, A. Nasrolahi Shirazi, D. Mandal, K. Parang, A. Foroumadi. Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as src kinase inhibitors. J of Sciences Islamic Republic of Iran 26, 321-325, 2015
27. S. Jena, B. Das, R. Bosu, M. Suar, D. Mandal*. Bacteria generated antibacterial gold nanoparticles and potential mechanistic insight. J. of Cluster Science 26 (5), 1707-1721, 2015
28. A. N. Shirazi, K. L. Paquin, N. G. Howlett, D. Mandal, K. Parang. Cyclic peptide capped gold nanoparticles for enhanced siRNA delivery. Molecules 19, 13319-13331, 2014
29. D. Mandal*, A. N. Shirazi, K. Parang*. Self assembly of peptides to nanostructures. (Review) Org. Biomol. Chem. 12, 3544-3561, 2014
30. D. Mandal*, A. N. Shirazi, R. Tiwari, A. Banerjee, A. Yadav, K. Parang*. Self-Assembled Surfactant Cyclic Peptide Nanostructures as Stabilizing Agents. Soft Matter 9, 9465-9475, 2013
31. A. N. Shirazi, R. Tiwari, D. Oh, B. Sullivan, K. McCaffrey, D. Mandal, K. Parang. Surface Decorated Gold Nanoparticles by Linear and Cyclic Peptides as Molecular Transporters. Mol. Pharm. 10 (8), 3137–3151, 2013 (ISSN 1543-8384)
32. A. N. Shirazi, D. Mandal, R. Tiwari, L. Guo, W. Lu, K. Parang. Cyclic Peptide-Capped Gold Nanoparticles as Drug Delivery Systems. Mol. Pharm. 10(2), 500-11, 2013
33. A. N. Shirazi, R. K. Tiwari, A. Brown, D. Mandal, G. Sun, K. Parang. Cyclic Peptides Containing Tryptophan and Arginine as Src Kinase Inhibitors. Bioorg. Med. Chem. Lett. 23(11), 3230-4, 2013 (ISSN: 0960-894X)
34. H. K. Agarwal, B. S. Chhikara, S. Bhavaraju, D. Mandal, G. Doncel, K. Parang. Emtricitabine Prodrugs with Improved Anti-HIV Activity and Cellular Uptake. Mol. Pharm. 10(2), 467-76, 2013 (ISSN 1543-8384)
35. A.N. Shirazi, R. Tiwari, B. Chhikara, D. Mandal, K. Parang. Design and Evaluation of Cell-Penetrating Peptide-Doxorubicin Conjugates as Prodrugs. Mol. Pharm. 10(2), 488-99, 2013 (ISSN 1543-8384)
36. B. S. Chhikara, D. Mandal, K. Parang. Synthesis, Anticancer Activities, and Cellular Uptake Studies of Lipophilic Derivatives of Doxorubicin Succinate. J. Med. Chem. 55, 1500, 2012 (ISSN 0022-2623)
37. R. K. Sharma, S. Singh, R. Tiwari, D. Mandal, C. E. Olsen, V. S. Parmar, K. Parang, Prasad AK. O-Aryl α,β-d-ribofuranosides: synthesis & highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity. Bioorg Med Chem. 20(23), 6821, 2012 (ISSN-09680896)
38. A. Rafinejad, A. Fallah-Tafti, R. Tiwari, A. N. Shirazi, D. Mandal, A. Shafiee, K. Parang, Alireza Foroumadi, Tahmineh Akbarzadeh. 4-Aryl-4H-naphthopyrans derivatives: One-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities. DARU Journal of Pharmaceutical Sciences 20,100, 2012
39. D. Mandal, A. Shirazi, K. Parang. Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters. Angew. Chem., Int. Ed. 50 (41), 9633, 2011 (ISSN: 1521-3773)
40. H. K. Agarwal, K. A. Loethen, D. Mandal, G. F Doncel, K. Parang. Synthesis and biological evaluation of Fatty Acyl Ester Derivatives of 2',3'-Didehydro-2',3'-Dideoxythymidine. Bioorg. Med. Chem. Lett. 21, 1917, 2011 (ISSN: 0960-894X )
41. B. S. Chhikara, D. Mandal, K. Parang. Fatty-Acyl Amide Derivatives of Doxorubicin: Synthesis and In Vitro Anticancer Activities. Eur. J. Med. Chem. 46(6), 2037, 2011 (ISSN. 0223-5234)
42. A. Gupta, D. Mandal, Y. Ahmadibeni, K. Parang, G. Bothun. Hydrophobicity Drives the Non-specific Cellular Uptake of Short Cationic Peptide Ligands. Eur. Biophysical J. 40(6), 727, 2011 (ISSN: 0175-7571)
43. A. Fallah-Tafti, R. Tiwari, A. N. Shirazi, T. Akbarzadeh, D. Mandal, A. Shafiee, K. Parang, A. Foroumadia. 4-Aryl-4H-Chromene-3-Carbonitrile Derivatives: Evaluation of Src Kinase Inhibitory and Anticancer Activities. Med. Chem. 7 (5), 466, 2011 (ISSN: 1573-4064)
44. A. Kumar, I. Ahmad, B. S. Chhikara, R. Tiwari, D. Mandal, K. Parang. Synthesis of 3-Phenylpyrazolopyrimidine-1,2,3-Triazole Conjugates and Evaluation of their Src Kinase Inhibitory and Anticancer Activities. Bioorg. Med. Chem. Lett. 21, 1342, 2011 (ISSN: 0960-894X )
45. D. Kumar, V. Buchi Reddy, A. Kumar, D. Mandal, R. Tiwari, and K. Parang. Click chemistry inspired one-pot synthesis of novel 1, 2, 3-triazoles and their Src kinase inhibitory activity. Bioorg. Med. Chem. Lett. 21, 449, 2011.
46. B. S. Chhikara, D. Mandal, K. Parang. Synthesis and evaluation of fatty acyl esters derivatives of cytarabine as anti-leukemia agents. Eur J Med Chem 45, 4601, 2010 (ISSN. 0223-5234)
47. D. Sharma, R. K. Sharma, S. Bhatia, R. Tiwari, D Mandal, J. Lehmann, K. Parang, C.E. Olsen, V. S. Parmar, A. K. Prasad. Synthesis, Src kinase inhibitory and anticancer activities of 1-substituted 3 (N-alkyl-N-phenylamino) propan-2-ols. Biochimie 92, 1164, 2010. (ISSN: 0300-9084)
48. Y. Wang, D. Mandal, S. Wang, E. Kleinerman, R. Pollock, D. Lev, A. Hayes-Jordan. Platelet Derived Growth Factor Receptor Beta Inhibition Increases Tumor Necrosis Factor Related Apoptosis Inducing Ligand sensitivity: Imatinib, TRAIL dual Therapy. Cancer 116, 3892, 2010 (ISSN: 1097-0142)
49. Y. X. Wang, D. Mandal, S. Wang, D. Hughes, R. E. Pollock, D. Lev, E. Kleinerman, A. Hayes-Jordan. Inhibiting Platelet Derived Growth Factor Beta (PDGFR-B) decreases Ewing’s Sarcoma Growth and Metastasis in a Novel Orthotopic Human Xenograft Model. In Vivo 23, 903, 2009 (ISSN: 1791-7549)
50. D. Mandal*, A. Maran, M. J. Yaszemski, M E Bolander and G Sarkar. Cellular uptake of gold nanoparticles directly cross-linked with carrier peptides by Osteosarcoma cells. J. Mater. Sci: Mater. Med. 20, 347, 2009 (ISSN: 1573-4838)
51. Y. Wang, D. Mandal, Andrea Hayes-Jordan. Platelet derived growth factor beta (PDGF-B), is required for pericyte requirement and angiogenesis in Fibrosarcoma. J. Am. College of Surgeons 205, 3, 2007
52. D. Mandal, A. Srivastava, E. Mahlum, D. Desai, A. Maran, M. Yaszemski, S. M. Jalal, S. Gitelis, F. Bertoni, T. Damron, R. Irwin, M. O. Connor, H. Schwartz, M. E. Bolander and G. Sarkar. Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma. Gene 386, 131, 2007 (ISSN: 0378-1119)
53. E. Mahlum, D. Mandal, C. Halder, A. Maran, M. J. Yaszemski, R. B. Jenkins, M. E. Bolander, G. Sarkar. Engineering a non-carrier to a carrier peptide for non-covalently delivering biologically active proteins into human cells. Anal Biochem 365, 215, 2007 (ISSN: 0003-2697)
54. D. Mandal*, M. E. Bolander, D. Mukhopadhyay, G. Sarkar and P. Mukherjee. The use of microorganisms for synthesis of metal nanoparticles and their application (Minireview). Applied Microbiol and Biotechnol 69, 485, 2006 (ISSN: 1432-0614)
55. H. M. Gardimalla, D. Mandal, P. Stevens, M. Yen, and Y. Gao. Superparamagnetic nanoparticle supported enzymatic resolution of racemic carboxylates. Chem. Commun. 4432, 2005 (ISSN : 1359-7345)
56. D. Mandal, A. Ahmad, M. I. Khan and R. Kumar. Enantioselective bioreduction of acetophenone and its analogous by the fungus Trichothecium sp. J. Mol. Catal. B: Enzym. 27, 61, 2004 (ISSN 1381-1177)
57. A. Ahmad, P. Mukherjee, S. Senapati, D. Mandal, M. I. Khan, R. Kumar and Murali Sastry. Extracellular biosynthesis of silver nanoparticles using the fungus Fusarium oxysporum. Coll. and Surf. B: Biointerfaces 28, 313, 2003 (ISSN: 0021-9797)
58. P. Mukherjee, S. Senapati, D. Mandal, A. Ahmad, M. I. Khan, R. Kumar and M. Sastry. Extra-cellular Synthesis of Gold Nanoparticles by the Fungus, Fusarium oxysporum. ChemBioChem. 3, 461, 2002 (ISSN: 1439-4227)
59. D. Mandal, A. Ahmad, M. I. Khan and R. Kumar. Biocatalytic transformation of cyclohexanone by Fusarium sp. J. Mol. Catal. A: Chemical 181, 237, 2002 (ISSN 1381-1169)
60. A. Ahmad, P. Mukherjee, D. Mandal, S. Senapati, M. I. Khan, R. Kumar and M. Sastry. Enzyme mediated Extracellular synthesis of CdS nanoparticles by the fungus Fusarium oxysporum. J. Am. Chem. Soc. 124, 12108, 2002 (ISSN:0002-7863)
61. P. Mukherjee, A. Ahmad, D. Mandal, S. Senapati, S. R. Sainkar, M. I. Khan, R. Parishcha, P. V. Ajayakumar, M. Alam, R. Kumar and M. Sastry. Fungus mediated synthesis of silver nanoparticle and their immobilization in the mycelial matrix: A novel biological approach to nanoparticle synthesis. Nano Lett 1, 515, 2001 (ISSN 1530-6984)
62. P. Mukherjee, A. Ahmad, D. Mandal, S. Senapati, S. R. Sainkar, M. I. Khan, R. Ramani, R. Parishcha, P. V. Ajayakumar, M. Alam, R. Kumar and M. Sastry, Bioreduction of AuCl4- ions by the fungus, Verticillium and surface trapping of gold nanoparticle thus formed. Angew. Chem. Int. Ed. Engl. 40, 3585, 2001 (ISSN: 1521-3773)
63. P. Mukherjee, S. Laha, D. Mandal, and R. Kumar. Organo-functionalized surface modified MCM-41 type mesoporous materials having various organic functional groups. Stud. Surf. Sci. Catal. 129, 283, 2000

Books :
1. Dindyal Mandal, Rohit Kumar Singh, Uday Suryakant Maharana, Bijayananda Panigrahi, Sourav Mishra. Microbial gold nanoparticles and their biomedical applications. In: Microbial Interactions at Nanobiotechnology Interfaces: Molecular Mechanisms and Applications. Wiley, 29 September 2021

1. Sourav Mishra, Rohit Kumar Singh, Uday Suryakanta, Bijayananda Panigrahi, and Dindyal Mandal*. Benefits of Nanomaterials-Based Biosensors. In: Biotechnological Advances for Microbiology, Molecular Biology, and Nanotechnology, Apple Academic Press, 2022 (ISBN: 9781771889995)

2. Bijayananda Panigrahi, Uday Suryakanta, Sourav Mishra, Rohit Kumar Singh, and Dindyal Mandal*. Role of Nanotechnology in Tissue Engineering and Regenerative Medicine. In: Biotechnological Advances for Microbiology, Molecular Biology, and Nanotechnology, Apple Academic Press, 2022 (ISBN: 9781771889995)

3. D. Mandal*, S. Mishra and R. K. Singh. Green Synthesized Nanoparticles as Potential Nanosensors. In: Environmental, Chemical and Medical Sensors, pp 137-164, 2018 (ISBN: 978-981-10-7750-0), Springer Nature.

4. D. Mandal. Intracellular delivery of gold nanoparticles: Application in nanomedicine. In: Biomaterials Developments and Applications, pp 435-451, 2010 (ISBN: 978-1-60876-476-1), Nova Publishers, NY, USA.


1. K. Parang, H. Montazeri, D. Mandal, E. Mohammed, S. Mozaffari, S. Lohan. Compositions and methods for siRNA delivery. U.S. Patent Application No. 62/953365 (2019)
2. Parang, K., Tiwari, R., Lohan S., Mohammed, E., Dindyal Manal, Synthetic antimicrobial peptides. 62/893450 (2019)
3. G. Sarkar, M. E. Bolander, D. Mandal, E. Mahlum, M. J. Yaszemski. Transport of biologically active molecules into a cell, mitochondrion, or nucleus. US pat application no 12/354,142 (2008)
4. P. Mukherjee, D. Mandal, A. Ahmad, M. Sastry and R. Kumar. Process for the preparation of metal sulfide nanoparticles. US Pat. 6, 783, 963 (2004)
5. D. Mandal, A. Ahmad, M. I. Khan and R. Kumar. Process for preparation of lactone from a cyclic ketone. US Pat. 6, 559, 322 (2003)
6. P. Mukherjee, D. Mandal, A. Ahmad, M. Sastry and R. Kumar. Process for the Preparation of a nanosized colloidal metal particle. U.S. Pat. 6, 537, 344 (2003)
7. P. Mukherjee, A. Ahmad, D. Mandal, S. Senapati, M. I. Khan, M. Sastry and R. Kumar. Process for the preparation of immobilized nanoparticles. US pat. 7, 759, 098 (2010)