Naresh Chandra Bal

Associate Professor

Naresh Chandra Bal has been a biology enthusiast since childhood, became focused on organismal physiology during his master’s degree in physiology from the School of Life Sciences, Sambalpur University in 1997. To add structural knowledge to his physiological understanding, he pursued PhD at the Central Drug Research Institute (CDRI), Lucknow. He was awarded PhD degree by Jawaharlal Nehru University (JNU). After PhD, he carried out research in several institutes in the USA for more than 8 years using various transgenic mouse models. Several major discoveries to his credit are sarcolipin as a basis of nonshivering thermogenesis in the skeletal muscle, functional interplay between muscle and brown adipose tissue, muscle-energy expenditure in causation of obesity, role of muscle thermogenesis in evolution of mammalian endothermy All these studies are published in high impact journals like Nature Medicine, Biological Reviews, and Journal of Biological Chemistry. He has been invited to present his research work at several important meetings including the Annual Scientific Meeting of The Obesity Society, 2009 and awarded with several reputed fellowships including American Physiological Society (APS), American Heart Association (AHA), National Institute of Health (NIH), Department of Biotechnology (DBT, India).

Profile Links

Email :
[email protected]
Website :
sites.google.com
Scopus Id :
36883500900
Google Scholar :
https://scholar.google.co.in/citations?hl=en&user=zdMLGbYAAAAJ&view_op=list_works&authuser=1

Social Links

Educational Qualification
M.Sc.; Ph.D.

Projects
  1. Extramural grant from Department of Biotechnology, India. Project Title: Targeting sarcolipin-based muscle energy expenditure to provide protection against type II diabetes. Duration: 10/2019 to 09/2022.
  2. Early Career Research Award, Science and Engineering Research Board (SERB); Department of Science and Technology, India. Project Title: Miscommunication between skeletal muscle and adipose tissues as an initiating factor of diabetic condition. Duration: 05/2017 to 04/2020
  3. Ramalingaswami Re-entry Fellowship 2014-15 from the Department of Biotechnology, India. Project Title: Functional genomics of skeletal muscle: role in diabetes and metabolic disorders. Duration: 07/2016 to 06/2021
Completed/Concluded: 1. Identification of enhancer of muscle-based energy expenditure via increasing SLN/SERCA interaction. K01 from National Institute of Health, NIDDK. 08/2015 to 07/2018. Concluded on 06/24/2016. 2. Sarcolipin: The key determinant of muscle mediated thermogenesis; American Heart Association; 07/2010 to 06/2012. 3. Sarcolipin is a key player in muscle based thermogenesis; American Physiological Society; 03/2010 to 03/2011.

Administrative Responsibility
Member of R&D Committee, KSBT; Member of Student Training, KSBT

Awards & Honours
  1. Visiting Professorship, University of Central Florida, Orlando USA (2019)
  2. Visiting Scholarship, University of Central Florida, Orlando USA (2018)
  3. Early Career Research Award, SERB, DST, India (2017)
  4. Visiting Scholarship, SBPMRI, Orlando USA (2016)
  5. Ramalingaswami Re-entry Fellowship, Dept. of Biotechnology, India (2016)
  6. NIH-K01 Award from NIDDK, NIH, USA (2015)
  7. Postdoctoral Recognition, The Ohio State University (2011)
  8. Postdoctoral Fellowship from American Heart Association (2010)
  9. Physiological Genomics Fellowship, American Physiological Society (2010)
  10. Junior Research Fellowship, CSIR. Ranked among Top 20% in India (2002)


Memberships
  1. American Physiological Society
  2. American Society for Biochemistry and Molecular Biology
  3. Indian Society of Chemists and Biologists
  4. Indian Society of Translational Research


      5. Outreach Activity
      Involved in transferring science and technology to tribal people in Sundargarh district of Orissa from 1998 to 2001
Journals/Conferences :
1. Bal, N., C.; Maurya, S., K.; Saporiwala, D., H.; Sahoo, S., K.; Gupta, S., C.; Shaikh, S., A.; Pant, M.; Rowland, L., A.; Bombardier, E.; Goonasekera, S.; A.; Tupling, A., R.; Molkentin, J., D. & Periasamy, M. (2012). Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Nature Medicine. 18(10):1575-9.
2. Rowland, L., A.; Bal, N., C. & Periasamy, M. (2015). The role of skeletal muscle-based thermogenic mechanisms in vertebrate endothermy. Biological Reviews. 90(4):1279-97.
3. Pant, M.; Bal, N., C. & Periasamy, M. (2016). Sarcolipin: key thermogenic and metabolic regulator in skeletal muscle. Trends in Endocrinology & Metabolism. 27(12):881-892.
4. Bal, N. C.; Singh, S.; Reis, F., C., G.; Maurya, S., K.; Pani, S.; Rowland, L., A. & Periasamy, M. (2017). Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice. Journal of Biological Chemistry. 292(40):16616-16625.
5. Bal, N., C.; Maurya, S., K.; Singh, S.; Wehrens, X., H.; & Periasamy, M. (2016). Increased reliance on muscle based thermogenesis upon acute minimization of brown adipose tissue function. Journal of Biological Chemistry. 291(33): 17247-57.
6. Rowland, L., A.; Bal, N., C.; Kozak, L., P. & Periasamy, M. (2015). Uncoupling Protein 1 and Sarcolipin are required to maintain optimal thermogenesis and loss of both systems compromises survival of mice under cold stress. Journal of Biological Chemistry. 290(19): 12282-9.
7. Maurya, S., K.; Bal, N., C.; Saporiwala, D., H.; Pant, M.; Rowland, L., A.; Shaikh, S., A. & Periasamy, M. (2015). Sarcolipin is a key determinant of basal metabolic rate and its overexpression enhances energy expenditure and resistance against diet induced obesity. Journal of Biological Chemistry. 290(17): 10840-9.
8. Sahu, B.; Pani, S.; Swalsingh, G.; & Bal, N., C. (2019). Epigenetic mechanisms in regulation of adaptive thermogenesis in skeletal muscle. Frontiers in Endocrinology. 10. 517.
9. Chakravarty, H.; Bal, C.; Yadav, M.; Jena, N.; Bal, N., C. & Sharon, A. (2019). First Insight on Small Molecules as Cardiac Calsequestrin Stabilizers. ACS Omega 4, 7, 11508.
10. Bal, N., C.; Maurya, S., K.; Pani, S.; Sethy, C.; Banerjee, A.; Das, S.; Patnaik, S.; & Kundu, C., N. (2017). Mild cold induced thermogenesis: are BAT and skeletal muscle synergistic partners? Bioscience Reports. 37(5).

Books :
1. Bal, N., C.; Maurya, S., K.; Saporiwala, D., H.; Sahoo, S., K.; Gupta, S., C.; Shaikh, S., A.; Pant, M.; Rowland, L., A.; Bombardier, E.; Goonasekera, S.; A.; Tupling, A., R.; Molkentin, J., D. & Periasamy, M. (2012). Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Nature Medicine. 18(10):1575-9.
2. Rowland, L., A.; Bal, N., C. & Periasamy, M. (2015). The role of skeletal muscle-based thermogenic mechanisms in vertebrate endothermy. Biological Reviews. 90(4):1279-97.
3. Pant, M.; Bal, N., C. & Periasamy, M. (2016). Sarcolipin: key thermogenic and metabolic regulator in skeletal muscle. Trends in Endocrinology & Metabolism. 27(12):881-892.
4. Bal, N. C.; Singh, S.; Reis, F., C., G.; Maurya, S., K.; Pani, S.; Rowland, L., A. & Periasamy, M. (2017). Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice. Journal of Biological Chemistry. 292(40):16616-16625.
5. Bal, N., C.; Maurya, S., K.; Singh, S.; Wehrens, X., H.; & Periasamy, M. (2016). Increased reliance on muscle based thermogenesis upon acute minimization of brown adipose tissue function. Journal of Biological Chemistry. 291(33): 17247-57.
6. Rowland, L., A.; Bal, N., C.; Kozak, L., P. & Periasamy, M. (2015). Uncoupling Protein 1 and Sarcolipin are required to maintain optimal thermogenesis and loss of both systems compromises survival of mice under cold stress. Journal of Biological Chemistry. 290(19): 12282-9.
7. Maurya, S., K.; Bal, N., C.; Saporiwala, D., H.; Pant, M.; Rowland, L., A.; Shaikh, S., A. & Periasamy, M. (2015). Sarcolipin is a key determinant of basal metabolic rate and its overexpression enhances energy expenditure and resistance against diet induced obesity. Journal of Biological Chemistry. 290(17): 10840-9.
8. Sahu, B.; Pani, S.; Swalsingh, G.; & Bal, N., C. (2019). Epigenetic mechanisms in regulation of adaptive thermogenesis in skeletal muscle. Frontiers in Endocrinology. 10. 517.
9. Chakravarty, H.; Bal, C.; Yadav, M.; Jena, N.; Bal, N., C. & Sharon, A. (2019). First Insight on Small Molecules as Cardiac Calsequestrin Stabilizers. ACS Omega 4, 7, 11508.
10. Bal, N., C.; Maurya, S., K.; Pani, S.; Sethy, C.; Banerjee, A.; Das, S.; Patnaik, S.; & Kundu, C., N. (2017). Mild cold induced thermogenesis: are BAT and skeletal muscle synergistic partners? Bioscience Reports. 37(5).