Rajani Kanta Mahapatra
Rajani Kanta Mahapatra
Associate Professor
Dr. Mahapatra has more than 12 years of experience in teaching at the post graduate and undergraduate level. He has completed his PhD in Computer-Aided Drug Design and his area of research is comparative genomics, molecular modeling and chemo-informatics.
Profile Links
Email :
[email protected]
Scopus Id :
54935290500
Google Scholar :
https://scholar.google.com/citations?user=6y711LwAAAAJ&hl=en&oi=ao
Social Links
Educational Qualification
PhD
Projects
Awards & Honours
PhD
Projects
- Machine learning approach for druggability prediction and prioritization of essential hypothetical genes in Plasmodium falciparum genome and virtual screening of PATHOGEN BOX small molecule inhibitors through molecular modeling study” approved by SERB, Govt. of India under MATRICS scheme from 2022-2025.
- Development of Electronic Medical Record (EMR) registry and machine learning model for prediction of diabetic nephropathy using renal biomarkers and clinical data” approved by ICMR, Govt. of India under Ad-hoc scheme from 2023-2026.
- Development of an Electronic Medical Record (EMR) registry and AI (Artificial Intelligence) model for prediction of mortality in liver cirrhosis using hepatic biomarkers and clinical data” approved by SERB, Govt. of India under CRG scheme from 2023-2026
Awards & Honours
- SERB International Research Experience (SIRE) fellowship by DST, Govt. of India.
- Best oral presentation award in the national seminar held on the occasion of 22 nd , 19 th Odisha Bigyan ‘O’ Paribesh Congress (2021 & 2017) and 16 th Odisha Bigyan Congress (2013).
- Adjudged as ‘A’ grade employee and letter for appreciation based on the performance by the reviewing authority of KIIT Deemed to be University, Bhubaneswar (An Institute of Eminence recognised by UGC, New Delhi).
- Awarded travel grant (DBT/CTEP/02/201100924) from Department of Biotechnology, Government of India to participate in InCOB-2011 from 30 th Nov-2 nd Dec, 2011 at Kuala Lumpur, Malaysia.
- Studentship sponsored by Department of Biotechnology, Government of India for pursuing Adv. PG Diploma in Bioinformatics for the academic year 2005-06.
- Recognized as an external examiner of Sambalpur University and visiting professor of Ramadevi Women’s University for the subject Bioinformatics and advisory board member of Department of Bioinformatics, BJB(Autonomous) College, Bhubaneswar.
Journals/Conferences :
1. Aregitu Mekuriaw Arega , Ajit Kumar Dhal, Kali Prasad Pattanaik, Sasmita Nayak, Rajani Kanta Mahapatra*(2023).An immunoinformatic based study of Mycobacterium tuberculosis Region of Difference-2 uncharacterized protein (Rv1987) as a potential subunit vaccine candidate for preliminary ex-vivo analysis. Applied Biochemistry and Biotechnology (Accepted) IF:3.0
2. Mohammad Mustafa Kazan, Misgana Mengistu Asmare, Rajani Kanta Mahapatra*(2023). Identification of potential drug targets in erythrocyte invasion pathway of Plasmodium falciparum. Current Microbiology 80(5):165. IF:2.6
3. Ssemuyiga Charles, Mulumba Pius Edgar, Rajani Kanta Mahapatra*(2023). Artificial intelligence based virtual screening study for competitive and allosteric inhibitors of the SARS-CoV-2 main protease. J of Biomolecular Structure and Dynamics (Accepted), DOI:
10.1080/07391102.2023.2188419, IF:4.4
4. Chinmaya Panda, Rajani Kanta Mahapatra*(2023). Bi-directional relationship between autophagy and inflammasomes in neurodegenerative disorders. Cellular and Molecular
Neurobiology, 43(1):115–137, IF:4.0
5. Ajit Kumar Dhal, Chinmaya Panda, Soon-IL Yun*, Rajani Kanta Mahapatra** (2022). An update on Cryptosporidium biology and therapeutic avenue. J of Parasitic
Disease, 46(3):923–939.
6. Chinmaya Panda, Rajani Kanta Mahapatra* (2022). An update on cerebral malaria for therapeutic intervention. Molecular Biology Reports, 49(11):10579–10591 IF:2.8
7. Aregitu Mekuriaw Arega, Ajit Kumar Dhal, Sasmita Nayak, Rajani Kanta Mahapatra* (2022). In silico and in vitro study of Mycobacterium tuberculosis H37RV uncharacterized protein (RipD): an insight on tuberculosis therapeutics. J of Molecular Modeling, 28(6):171, DOI: https://doi.org/10.1007/s00894-022-05148-1 IF:2.2
8. Ajit Kumar Dhal, Glenn M Young, Soon-IL Yun*, Rajani Kanta Mahapatra* (2022). Computational analysis of Elongation Factor-2 (EF-2) protein of Cryptosporidium parvum for identification of therapeutics. Biologia, 77(5): 1447–1457 IF:1.5
9. Misgana Mengistu Asmare, Nitin Nitin, Soon-IL Yun*, Rajani Kanta Mahapatra** (2022). QSAR and DEEP LEARNING model for virtual screening of potential inhibitors against Inosine 5’ Monophosphate dehydrogenase (IMPDH) of Cryptosporidium parvum. J of Molecular Graphics and Modeling, 111:108108 IF:2.9
10. Nitika Pradhan, Rajani Kanta Mahapatra, Rupenangshu. K Hazra (2022). The Plasmodium falciparum infection status of two major anopheline vectors in three hyper- meso-, and hypoendemic districts in Odisha, India. The Canadian Entomologist, 154(1) e16 IF: 0.9
11. Aregitu Mekuriaw Arega, Rajani Kanta Mahapatra* (2021). Glycoconjugates, hypothetical proteins and post translational modification: impact in host pathogen interaction and antitubercular intervention development. Chemical Biology and Drug Design,98(1):30–48 IF:3.0
12. Aregitu Mekuriaw Arega, Kali Prasad Pattanaik, Sasmita Nayak, Rajani Kanta Mahapatra* (2021). Computational discovery and experimental validation of novel immunogenic vaccine candidates against tuberculosis. Acta Tropica. 217:105870 IF:2.7
13. Ajit Kumar Dhal, Alok Pani, Soon-IL Yun*, Rajani Kanta Mahapatra* (2020). In silico analysis of Cryptosporidium parvum CDPK6 protein through molecular modeling, docking and molecular dynamics simulation study. J of Bimolecular Structure and Dynamics, 39(15): 5461–5470 IF:4.4
14. Rajani Kanta Mahapatra*, Mahin Das (2020). A computational approach to validate novel drug targets of gentianine from Swertiya chirayita in Plasmodium falciparum. BioSystems,196: 104175 IF:1.6
15. Ajit Kumar Dhal, Alok Pani, Rajani Kanta Mahapatra*, Soon-IL Yun* (2019). An immunoinformatics approach for design and validation of multi-subunit vaccine against Cryptosporidium parvum. Immunobiology, 224(6):747–757 IF:2.8
16. Somdeb Chattopadhyay, Rajani Kanta Mahapatra* (2019). Identification of adaptive inhibitors of Cryptosporidium parvum fatty acyl-coenzyme A synthetase isoforms by virtual screening. Parasitology Research, 118(11):3159-3171 IF:2.0
17. Subhashree Rout, Rajani Kanta Mahapatra* (2019). In silico study of M18 aspartyl amino peptidase of Plasmodium vivax as therapeutic candidate. Bio-organic and Medicinal Chemistry,27(12):2553-2571 IF: 3.5
18. Subhashree Rout, Rajani Kanta Mahapatra* (2019). Plasmodium falciparum: Multidrug resistance. Chemical Biology and Drug Design, 93(5):737-759. IF: 3.0
19. Subhashree Rout, Rajani Kanta Mahapatra* (2018). In silico analysis of Plasmodium falciparum CDPK5 protein through molecular modeling, docking and dynamics simulation. J of Theoretical Biology, 461: 254–267. IF: 2.0
20. Ajit Kumar Dhal, Alok Pani, Rajani Kanta Mahapatra*, Soon-IL Yun* (2018). In silico screening of novel small molecule inhibitors against Lactate Dehydrogenase (LDH) of Cryptosporidium parvum. Computational Biology and Chemistry,77:44-51. IF:3.1
21. Chinmaya Panda, Rajani Kanta Mahapatra* (2018). Identification of novel therapeutic candidates in Cryptosporidium parvum: An in-silico approach. Parasitology 145(14):1907-1916. IF: 2.4
22. Subhashree Rout, Namrata Priyadarshini Patra, Rajani Kanta Mahapatra* (2017). An in-silico strategy for identification of novel drug targets in Plasmodium falciparum. Parasitology Research, 116(9): 2539–2559. IF: 2.0
23. Arpit Kumar Shirvastava, Subrat Kumar, Priyadashi Soumyaranhan Sahu*, Rajani Kanta Mahapatra* (2017). In silico identification and validation of a novel hypothetical protein in Cryptosporidium hominis and virtual screening of inhibitors as therapeutics. Parasitology Research, 116(5): 1533-1544. IF: 2.0
24. Sandeep Kumar Panda, Rajani Kanta Mahapatra* (2017). In-silico screening, identification and validation of a novel vaccine candidate in the fight against Plasmodium falciparum. Parasitology Research, 116(4):1293-1305. IF: 2.0
25. Subhashree Rout, Rajani Kanta Mahapatra* (2016). In-silico screening of novel inhibitor of M17 Leucine Amino Peptidase (LAP) of Plasmodium vivax as therapeutic candidate. Biomedicine & Pharmacotherapy, 82:192–201. IF:7.5
26. Jugal Kishore Das, Rajani Kanta Mahapatra, Subhranshu Patro, Chandan Goswami, Mrutyunjay Suar* (2016). Lactobacillus acidophilus binds to MUC3 component of cultured intestinal epithelial cells with highest affinity. FEMS Microbiology Letters, 363(8). IF: 2.1
27. Himanshu Bhusan Samal, Jugal Kishore Das, Rajani Kanta Mahapatra*, Mrutunjay Suar* (2015). Molecular modeling, simulation and virtual screening of MurD ligase protein from Salmonella Typhimurium LT2. J of Pharmacological and Toxicological Methods, 73: 34-41 IF:1.9
28. Himanshu Bhusan Samal, Jyoti Prava, Mrutunjay Suar, Rajani Kanta Mahapatra* (2015). Comparative genomics analysis of Salmonella Typhimurium LT2 for the identification of putative therapeutic candidate. J. of Theoretical Biology, 369:67-79 IF: 2.0
29. Subhashree Rout, David Charles Warhurst, Mrutyunjay Suar, Rajani Kanta Mahapatra* (2015). In-silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates. J. of Microbiological Methods, 109: 1-8. IF: 2.2
30. Soma Ghosh, Jyoti Prava, Himanshu Bhusan Samal, Mrutunjay Suar, Rajani Kanta Mahapatra* (2014). Comparative genomics for the identification of drug and vaccine targets in Staphylococcus aureus. MurA ligase enzyme as a proposed candidate. J. of Microbiological Method, 101:1-8. IF: 2.2
31. Parmita Chawley, Himanshu Bhusan Samal, Jyoti Prava, Mrutunjay Suar, Rajani Kanta Mahapatra* (2014). Comparative genomics study for identification of drug and vaccine targets in Vibrio cholerae: MurA ligase as a case study. Genomics, 103(1):83-93 IF: 4.4 (Illustrated on the cover page of the journal)
32. Alok Pani, Rajani Kanta Mahapatra* (2013). Computational identification of miRNAs and their targets in Catharanthus roseus expressed sequence tags. Genomics Data,1:2-6
33. Alok Pani, Rajani Kanta Mahapatra*, Niranjan Behera and Pradeep Kumar Naik (2011). Computational identification of Sweet Wormwood (Artemisia annua) miRNA and their mRNA targets. Genomics, Proteomics & Bioinformatics, 9(6): 200-210. IF:9.5
1. Aregitu Mekuriaw Arega , Ajit Kumar Dhal, Kali Prasad Pattanaik, Sasmita Nayak, Rajani Kanta Mahapatra*(2023).An immunoinformatic based study of Mycobacterium tuberculosis Region of Difference-2 uncharacterized protein (Rv1987) as a potential subunit vaccine candidate for preliminary ex-vivo analysis. Applied Biochemistry and Biotechnology (Accepted) IF:3.0
2. Mohammad Mustafa Kazan, Misgana Mengistu Asmare, Rajani Kanta Mahapatra*(2023). Identification of potential drug targets in erythrocyte invasion pathway of Plasmodium falciparum. Current Microbiology 80(5):165. IF:2.6
3. Ssemuyiga Charles, Mulumba Pius Edgar, Rajani Kanta Mahapatra*(2023). Artificial intelligence based virtual screening study for competitive and allosteric inhibitors of the SARS-CoV-2 main protease. J of Biomolecular Structure and Dynamics (Accepted), DOI:
10.1080/07391102.2023.2188419, IF:4.4
4. Chinmaya Panda, Rajani Kanta Mahapatra*(2023). Bi-directional relationship between autophagy and inflammasomes in neurodegenerative disorders. Cellular and Molecular
Neurobiology, 43(1):115–137, IF:4.0
5. Ajit Kumar Dhal, Chinmaya Panda, Soon-IL Yun*, Rajani Kanta Mahapatra** (2022). An update on Cryptosporidium biology and therapeutic avenue. J of Parasitic
Disease, 46(3):923–939.
6. Chinmaya Panda, Rajani Kanta Mahapatra* (2022). An update on cerebral malaria for therapeutic intervention. Molecular Biology Reports, 49(11):10579–10591 IF:2.8
7. Aregitu Mekuriaw Arega, Ajit Kumar Dhal, Sasmita Nayak, Rajani Kanta Mahapatra* (2022). In silico and in vitro study of Mycobacterium tuberculosis H37RV uncharacterized protein (RipD): an insight on tuberculosis therapeutics. J of Molecular Modeling, 28(6):171, DOI: https://doi.org/10.1007/s00894-022-05148-1 IF:2.2
8. Ajit Kumar Dhal, Glenn M Young, Soon-IL Yun*, Rajani Kanta Mahapatra* (2022). Computational analysis of Elongation Factor-2 (EF-2) protein of Cryptosporidium parvum for identification of therapeutics. Biologia, 77(5): 1447–1457 IF:1.5
9. Misgana Mengistu Asmare, Nitin Nitin, Soon-IL Yun*, Rajani Kanta Mahapatra** (2022). QSAR and DEEP LEARNING model for virtual screening of potential inhibitors against Inosine 5’ Monophosphate dehydrogenase (IMPDH) of Cryptosporidium parvum. J of Molecular Graphics and Modeling, 111:108108 IF:2.9
10. Nitika Pradhan, Rajani Kanta Mahapatra, Rupenangshu. K Hazra (2022). The Plasmodium falciparum infection status of two major anopheline vectors in three hyper- meso-, and hypoendemic districts in Odisha, India. The Canadian Entomologist, 154(1) e16 IF: 0.9
11. Aregitu Mekuriaw Arega, Rajani Kanta Mahapatra* (2021). Glycoconjugates, hypothetical proteins and post translational modification: impact in host pathogen interaction and antitubercular intervention development. Chemical Biology and Drug Design,98(1):30–48 IF:3.0
12. Aregitu Mekuriaw Arega, Kali Prasad Pattanaik, Sasmita Nayak, Rajani Kanta Mahapatra* (2021). Computational discovery and experimental validation of novel immunogenic vaccine candidates against tuberculosis. Acta Tropica. 217:105870 IF:2.7
13. Ajit Kumar Dhal, Alok Pani, Soon-IL Yun*, Rajani Kanta Mahapatra* (2020). In silico analysis of Cryptosporidium parvum CDPK6 protein through molecular modeling, docking and molecular dynamics simulation study. J of Bimolecular Structure and Dynamics, 39(15): 5461–5470 IF:4.4
14. Rajani Kanta Mahapatra*, Mahin Das (2020). A computational approach to validate novel drug targets of gentianine from Swertiya chirayita in Plasmodium falciparum. BioSystems,196: 104175 IF:1.6
15. Ajit Kumar Dhal, Alok Pani, Rajani Kanta Mahapatra*, Soon-IL Yun* (2019). An immunoinformatics approach for design and validation of multi-subunit vaccine against Cryptosporidium parvum. Immunobiology, 224(6):747–757 IF:2.8
16. Somdeb Chattopadhyay, Rajani Kanta Mahapatra* (2019). Identification of adaptive inhibitors of Cryptosporidium parvum fatty acyl-coenzyme A synthetase isoforms by virtual screening. Parasitology Research, 118(11):3159-3171 IF:2.0
17. Subhashree Rout, Rajani Kanta Mahapatra* (2019). In silico study of M18 aspartyl amino peptidase of Plasmodium vivax as therapeutic candidate. Bio-organic and Medicinal Chemistry,27(12):2553-2571 IF: 3.5
18. Subhashree Rout, Rajani Kanta Mahapatra* (2019). Plasmodium falciparum: Multidrug resistance. Chemical Biology and Drug Design, 93(5):737-759. IF: 3.0
19. Subhashree Rout, Rajani Kanta Mahapatra* (2018). In silico analysis of Plasmodium falciparum CDPK5 protein through molecular modeling, docking and dynamics simulation. J of Theoretical Biology, 461: 254–267. IF: 2.0
20. Ajit Kumar Dhal, Alok Pani, Rajani Kanta Mahapatra*, Soon-IL Yun* (2018). In silico screening of novel small molecule inhibitors against Lactate Dehydrogenase (LDH) of Cryptosporidium parvum. Computational Biology and Chemistry,77:44-51. IF:3.1
21. Chinmaya Panda, Rajani Kanta Mahapatra* (2018). Identification of novel therapeutic candidates in Cryptosporidium parvum: An in-silico approach. Parasitology 145(14):1907-1916. IF: 2.4
22. Subhashree Rout, Namrata Priyadarshini Patra, Rajani Kanta Mahapatra* (2017). An in-silico strategy for identification of novel drug targets in Plasmodium falciparum. Parasitology Research, 116(9): 2539–2559. IF: 2.0
23. Arpit Kumar Shirvastava, Subrat Kumar, Priyadashi Soumyaranhan Sahu*, Rajani Kanta Mahapatra* (2017). In silico identification and validation of a novel hypothetical protein in Cryptosporidium hominis and virtual screening of inhibitors as therapeutics. Parasitology Research, 116(5): 1533-1544. IF: 2.0
24. Sandeep Kumar Panda, Rajani Kanta Mahapatra* (2017). In-silico screening, identification and validation of a novel vaccine candidate in the fight against Plasmodium falciparum. Parasitology Research, 116(4):1293-1305. IF: 2.0
25. Subhashree Rout, Rajani Kanta Mahapatra* (2016). In-silico screening of novel inhibitor of M17 Leucine Amino Peptidase (LAP) of Plasmodium vivax as therapeutic candidate. Biomedicine & Pharmacotherapy, 82:192–201. IF:7.5
26. Jugal Kishore Das, Rajani Kanta Mahapatra, Subhranshu Patro, Chandan Goswami, Mrutyunjay Suar* (2016). Lactobacillus acidophilus binds to MUC3 component of cultured intestinal epithelial cells with highest affinity. FEMS Microbiology Letters, 363(8). IF: 2.1
27. Himanshu Bhusan Samal, Jugal Kishore Das, Rajani Kanta Mahapatra*, Mrutunjay Suar* (2015). Molecular modeling, simulation and virtual screening of MurD ligase protein from Salmonella Typhimurium LT2. J of Pharmacological and Toxicological Methods, 73: 34-41 IF:1.9
28. Himanshu Bhusan Samal, Jyoti Prava, Mrutunjay Suar, Rajani Kanta Mahapatra* (2015). Comparative genomics analysis of Salmonella Typhimurium LT2 for the identification of putative therapeutic candidate. J. of Theoretical Biology, 369:67-79 IF: 2.0
29. Subhashree Rout, David Charles Warhurst, Mrutyunjay Suar, Rajani Kanta Mahapatra* (2015). In-silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates. J. of Microbiological Methods, 109: 1-8. IF: 2.2
30. Soma Ghosh, Jyoti Prava, Himanshu Bhusan Samal, Mrutunjay Suar, Rajani Kanta Mahapatra* (2014). Comparative genomics for the identification of drug and vaccine targets in Staphylococcus aureus. MurA ligase enzyme as a proposed candidate. J. of Microbiological Method, 101:1-8. IF: 2.2
31. Parmita Chawley, Himanshu Bhusan Samal, Jyoti Prava, Mrutunjay Suar, Rajani Kanta Mahapatra* (2014). Comparative genomics study for identification of drug and vaccine targets in Vibrio cholerae: MurA ligase as a case study. Genomics, 103(1):83-93 IF: 4.4 (Illustrated on the cover page of the journal)
32. Alok Pani, Rajani Kanta Mahapatra* (2013). Computational identification of miRNAs and their targets in Catharanthus roseus expressed sequence tags. Genomics Data,1:2-6
33. Alok Pani, Rajani Kanta Mahapatra*, Niranjan Behera and Pradeep Kumar Naik (2011). Computational identification of Sweet Wormwood (Artemisia annua) miRNA and their mRNA targets. Genomics, Proteomics & Bioinformatics, 9(6): 200-210. IF:9.5
PhD Students Supervised
- Mr. Ajit Kumar Dhal bearing Registration No. 15546843606 has been awarded PhD degree for the thesis entitled as “Design of novel therapeutics against Cryptosporidium parvum: an in-silico approach” in my supervision videNotification No. KIIT-DU/Exam-Ph.D-161-106-AKD-
RKM-SBT-1610106/2022 on Date: 29.09.2022. - Mrs. Aregitu Mekuriaw Arega bearing Registration No. 17647958266 has been awarded PhD degree for the thesis entitled “Discovery of potent subunit vaccine and therapeutic candidates against tuberculosis: in-silico approach and its preliminary validation in ex-vivo model” for evaluation in my supervision vide Notification No. KIIT-DU/Exam-Ph.D-139-111-AMA-
RKM-SBT-1390111/2022 on Date: 23.09.2022. - Mrs. Subhashree Rout bearing Registration No. 13490632250 has been awarded PhD degree for the thesis entitled “Design of antimalarial drug molecules against Plasmodium species: Computational and experimental approach” in my supervision vide Notification No. KIIT-DU/Exam-Ph.D-02-14-SR-RKM-SBT-02014/2019 on Dt. 28/11/2019.
- Mrs. Nitika Pradhan bearing Registration No.13488632230 has been awarded PhD degree for the thesis entitled “Epidemiological and entomological profile of malaria in a hyper, meso and hypo-endemic district of Odisha, India” in my co-supervision vide Notification No. KIIT-DU/Exam-Ph.D-/51-42-NP-RKH-RKM-SBT-51142/2020 on Dt. 08/10/2020.