Srinivas Patnaik

Dean & Professor

Dr. Srinivas Patnaik earned his MSc in Biotechnology from Goa University and PhD from Institute of Life sciences, Bhubaneswar specialised in “Molecular Oncology”. Presently, Dr. Patnaik is working as an Professor and Dean in School of Biotechnology, KIIT University. Dr. Patnaik conferred the young scientist by Department of Science and Technology, Odisha and have received STA fellowship from IARC, World Health Organisation, Lyon, France. Dr. Patnaik, had 12-year experience working in USA and Europe with eminent scientists in the field of DNA repair and cancer. He has published research articles in high impact journals such as Gastroenterology, Cancer Research, Oncogene, Nucleic Acid Research to name a few. Dr. Patnaik has been member of several national and international scientific societies and is actively serving in the review board in many international journals such cancer letters, Scientific Reports, Cellular and Molecular Biochemistry etc. Apart from research, Dr. Patnaik has been a passionate teacher and involved in teaching molecular biology, genetic engineering and cell biology. In addition to the core topics he is interested and involved in teaching soft skills such as "personality development and scientific writing" to final year M Tech and MSc students. Currently his research group is working in the field of gastrointestinal inflammation and colorectal cancer using genetically modified mouse models.

Profile Links

Email :
[email protected]
Scopus Id :
7102590490
Google Scholar :
https://scholar.google.com/citations?user=E_f-JdwAAAAJ&hl=en

Social Links

Educational Qualification
Ph.D.

Projects
Principal Investigator
  • Development of novel muco-adhesive buccal patch for management or oral submucous fibrosis Dr. Srinivas Patnaik, Co-PI, ICMR, 2022-2025.
  • Validation of anti-cancer activity of phytochemicals from traditional herbal healing practices. National Innovation Foundation, DST. Completed: 31-03-2020
Mentor
  • Design and Evaluation of novel formulations of some anti- cancer drugs for metronomic chemotherapy BIG Grant, BIRAC, Department of Biotechnology, Govt. of India. Completed: 31-01-2017
Co- Principal Investigator
  • Evaluation of antileukemic and immunogenicity properties of engineered Eschericha coli asparaginase-II for the treatment of acute lymphatic leukemia in preclinical model, Department of Science and Technology, Govt. of India. Completed: 27-1-2019
Co-Principal Investigator
  • Multipronged approach for pre-clinical assessment of novel curcumin formulations as drugs for breast cancer therapy. Department of Biotechnology, Govt. of India. Ongoing: 2020-2023
Co- Principal Investigator
  • Understanding the enigma of interconnection between inflammatory bowel disease (IBD) and neurodegeneration utilizing genetically predisposed IBD mice model, Department of Health Research, ICMR. Ongoing: 2020-2023


Administrative Responsibility
Dean

Awards & Honours
  1. World Health Organisation (WHO) Fellowship (STA) for pursuing research on cancer at International Agency for Research on Cancer, IARC, Lyon, France. 2002
  2. Orissa Young Scientist Award, Department of Science and Technology, Orissa, India. 2000
  3. Senior Research Scholarship award by UGC, India. 1998
  4. Junior Research Scholarship award by UGC, India. 1996
  5. National Scholarship awarded by Department of Biotechnology, India. 1994


Memberships
  1. Associate Member: American Association for Cancer Research (AACR)
  2. Associate Member: American Gastroenterological Association (AGA)
  3. Life Member: Indian Association for Cancer Research (IACR) Member
  4. The International Mammalian Genome Society (IMGS)


    5. Outreach Activity
    Serving as reviewer in cancer letters, Scientific Reports, Cellular and Molecular Biochemistry. Associate editor journal- Health and Population: Perspectives and Issues (HPPI)
Journals/Conferences :
1. Esmaeilniakooshkghazi, A., Pham, E., George, S. P., Ahrorov, A., Villagomez, F. R., Byington, M., Khurana, S. (2023). In colon cancer cells fascin1 regulates adherens junction remodeling. FASEB Journal, 37(3) doi:10.1096/fj.202201454R

2. Sinha, A., Vaggu, R. G., Swain, R., & Patnaik, S. (2023). Repurposing of RAS-pathway mediated drugs for intestinal inflammation related diseases for treating SARS-CoV-2 infection. Current Microbiology, 80(6) doi:10.1007/s00284-023-03304-1

3. Lavudi, K., Harika, G. V. S., Thirunavukarasou, A., Govindarajan, G., Patnaik, S., Golla, N., Penchalaneni, J. (2023). Green synthesis of tecoma stans flower and leaf extracts: Characterization and anti-proliferative activity in colorectal cancer cell lines. Letters in Applied NanoBioScience, 12(3) doi:10.33263/LIANBS123.061

4. Kodidasu A, Satya HV, Lavudi K, Thirunavukarasou A, Patnaik S, Penchalaneni J. Effect of Probiotics on Allethrin Toxicity: an In Vivo Study Using Zebrafish Model (2023) Biointerface Research in Applied Chemistry, 13(5), 431. (IF: 2.23)

5. Lavudi K, Hemalatha S, Kokkanti RR, Harika GVS., Patnaik S, Penchalaneni J. Anti-tumour efficacy of Musa paradisiaca flower extracts on DMBA induced mammary carcinogenesis in female wistar rats (2022) South African Journal of Botany, 151(200-207). (IF: 3.11)

6. Sharma, S., Padhi, S., Kumari, M., Patnaik, S., Sahoo, D. Antioxidant Potential of Selected Wild Edible Leafy Vegetables of Sikkim Himalayan Region: Effects of Cooking Methods and Gastrointestinal Digestion on Activity (2022) Frontiers in Nutrition, 9, art. no. 861347. (IF: 6.59)

7. Mehto S, Jena KK, Yadav R, Priyadarsini S, Samal P, Krishna S, Dhar K, Jain A, Chauhan NR, Murmu KC, Bal R, Sahu R, Jaiswal P, Sahoo BS, Patnaik S, Kufer TA, Rusten TE, Chauhan S, Prasad P, Chauhan S. Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection (2022) EMBO Journal, 41 (23), e111289. (IF: 11.6)

8. Radharani, N.N.V., Yadav, A.S., Nimma, R., Kumar, T.V.S., Bulbule, A., Chanukuppa, V., Kumar, D., Patnaik, S., Rapole, S., Kundu, G.C. Tumor-associated macrophage derived IL-6 enriches cancer stem cell population and promotes breast tumor progression via Stat-3 pathway (2022) Cancer Cell International, 22 (1)122. (IF: 6.4)

9. Lavudi K, Harika VS, Kokkanti RR, Patchigolla S, Sinha A, Patnaik S, Penchalaneni J. 2-Dimensional in vitro culture assessment of ovarian cancer cell line using cost effective silver nanoparticles from Macrotyloma uniflorum seed extracts (2022) Frontiers in Bioengineering and Biotechnology, 10, 978846. (IF: 6.064)

10. S A, Chakraborty A, Patnaik S. Clonal evolution and expansion associated with therapy resistance and relapse of colorectal cancer (2022) Mutation Research - Reviews in Mutation Research, 790, 108445. (IF: 5.657)

11. Surve C, Banerjee A, Anupriya S, Chakraborty R, Kumar D, Butti R, Gorain M, Parida S, Kundu GC, Shidhaye S, Patnaik S. Antiproliferative and apoptotic potential of methotrexate lipid nanoparticles in a murine breast cancer model (2022) Nanomedicine, 17 (11),753-764. (IF: 6.096)

12. Banerjee A, Cai S, Xie G, Li N, Bai X, Lavudi K, Wang K, Zhang X, Zhang J, Patnaik S, Backes FJ, Bennett C, Wang QE. A Novel Estrogen Receptor β Agonist Diminishes Ovarian Cancer Stem Cells via Suppressing the Epithelial-to-Mesenchymal Transition. Cancers (Basel). 2022 May 6;14(9):2311. (IF: 6.575)

13. Goud VR, Chakraborty R, Chakraborty A, Lavudi K, Patnaik S, Sharma S, Patnaik S. A bioinformatic approach of targeting SARS-CoV-2 replication by silencing a conserved alternative reserve of the orf8 gene using host miRNAs. Comput Biol Med. 2022 Jun;145:105436. doi: 10.1016/j.compbiomed.2022.105436. Epub 2022 Mar 24. (IF: 5.59)

14. Berehu, H.M., Anupriya, S., Khan, M.I., Chakraborty, R., Lavudi, K., Penchalaneni, J., Mohapatra, B., Mishra, A., Patnaik, S. Cytotoxic Potential of Biogenic Zinc Oxide Nanoparticles Synthesized From Swertia chirayita Leaf Extract on Colorectal Cancer Cells. Front Bioeng. Biotechnol. (2021), 9, art. no. 788527 (IF: 5.48)

15. Nath P, Chauhan NR, Jena KK, Datey A, Kumar ND, Mehto S, De S, Nayak TK, Priyadarsini S, Rout K, Bal R, Murmu KC, Kalia M, Patnaik S, Prasad P, Reggiori F, Chattopadhyay S, Chauhan S. Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses. EMBO Rep. 2021 Nov 4;22(11):e52948. doi: 10.15252/embr.202152948. (IF: 8.8)

16. Elfawy HA, Anupriya S, Mohanty S, Patel P, Ghosal S, Panda PK, Das B, Verma SK, Patnaik S. Molecular toxicity of Benzo(a)pyrene mediated by elicited oxidative stress infer skeletal deformities and apoptosis in embryonic zebrafish. Sci of The Total Environment, Volume 789, 2021,147989. (IF:7.963)

17. Borah NA, Sradhanjali S, Barik MR, Jha A, Tripathy D, Kaliki S, Rath S, Raghav SK, Patnaik S, Mittal R, Reddy MM. Aurora Kinase B Expression, Its Regulation and Therapeutic Targeting in Human Retinoblastoma. Invest Ophthalmol Vis Sci. 2021 Mar 1;62(3):16. (IF: 3.812)

18. Surve C, Singh R, Banerjee A, Patnaik S, Shidhaye S. Formulation and qbd based optimization of methotrexate-loaded solid lipid nanoparticles for an effective anti-cancer treatment. Int J of App Pharmaceutics, Volume 13, Issue 5, Pages 132 – 143, September-October 2021 (IF: 2.012)

19. Kumar S, Patnaik S, Dixit A. Predictive models for stage and risk classification in head and neck squamous cell carcinoma (HNSCC). Peer J. 2020 Sep 22;8: e9656. doi: 10.7717/peerj.9656. (IF: 2.38)

20. Chakraborty R, Singha D, Kumar V, Pakrashi A, Kundu S, Chandra K, Patnaik S, Tyagi K. DNA barcoding of selected Scirtothrips species (Thysanoptera) from India. Mitochondrial DNA B Resour. 2019 Jul 24;4(2):2710-2714.

21. Patnaik S, Anupriya. Drugs Targeting Epigenetic Modifications and Plausible Therapeutic Strategies Against Colorectal Cancer. Front Pharmacol. 2019 Jun 6; 10: 588. (IF: 5.81)

22. Srivastava AK, Banerjee A, Cui T, Han C, Cai S, Liu L, Wu D, Cui R, Li Z, Zhang X, Xie G, Selvendiran K, Patnaik S, Karpf AR, Liu J, Cohn DE, Wang QE. Inhibition of miR-328-3p Impairs Cancer Stem Cell Function and Prevents Metastasis in Ovarian Cancer. Cancer Res. 2019 May 1;79(9):2314-2326 (IF: 12.531)

23. Chakraborty R, Tyagi K, Kundu S, Rahaman I, Singha D, Chandra K, Patnaik S, Kumar V. The complete mitochondrial genome of Melon thrips, Thrips palmi (Thripinae): Comparative analysis. PLoS One. 2018 Oct 31;13(10):e0199404.(IF: 2.74)

24. Roy S, Esmaeilniakooshkghazi A, Patnaik S, Wang Y, George SP, Ahrorov A, Hou JK, Herron AJ, Sesaki H, Khurana S. Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation. Gastroenterology. 2018 Apr;154(5):1405-1420 (IF: 22.682)

25. Patnaik S, George SP, Pham E, Swati R, Singh K, Mariadason JM, Khurana S. By moonlighting in the nucleus villin regulates epithelial plasticity. Mol Biol Cell. 2015 Dec 10. (IF: 4.8)

26. Wang Y, George SP, Srinivasan K, Patnaik S and Khurana S. Actin reorganization as the molecular basis for the regulation of apoptosis in gastrointestinal epithelial cells. Cell death and differentiation. 2012 Sep; 19 (9):1514-24. (IF: 15.828)

27. El-Mahdy MA, Zhu Q, Wang QE, Wani G, Patnaik S, Zhao Q, Arafa el-S, Barakat B, Mir SN, Wani AA. Naringenin Protects HaCaT Human Keratinocytes Against UVB-induced Apoptosis and Enhances the Removal of Cyclobutane Pyrimidine Dimers from the Genome. Photochem Photobiol. 2008 Mar-Apr; 84(2):307-16. (IF: 3.421)

28. Wang QE, Praetorius-Ibba M, Zhu Q, El-Mahdy MA, Wani G, Zhao Q, Qin S, Patnaik S, Wani AA. Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair. Nucleic Acids Res. 2007; 35(16):5338-50. (IF: 16.971)

29. Zhu Q, Wani G, Yao J, Patnaik S, Wang QE, El-Mahdy MA, Praetorius-Ibba M, Wani AA. The ubiquitin-proteasome system regulates p53-mediated transcription at p21waf1 promoter. Oncogene. 2007 Jun 21; 26(29):4199-208. (IF: 9.867)

30. Yang YG, Cortes U, Patnaik S, Jasin M and Wang ZQ. Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks,but compromises the reactivation of stalled replication forks. Oncogene 2004 Mar 15. (IF: 8.45)

31. Sahu GR, Nayak BK, Patnaik S, Parija T, Das BR. Rearrangement of p53 gene with overexpressed p53 protein in primary cervical cancer. Oncol Rep. 2002 Mar-Apr; 9(2): 433-7. (IF: 3.906)

32. Nagpal JK, Patnaik S, Das BR. Prevalence of high-risk human papilloma virus types and its association with P53 codon 72 polymorphism in tobacco addicted oral squamous cell carcinoma (OSCC) patients of Eastern India. Int J Cancer. 2002 Feb 10; 97(5): 649-53. (IF: 7.396)

33. Patnaik S, Nayak BK, Das BR. Rearrangement in the coding and 5' region of p53 gene in human oral tumors. IUBMB Life. 1999 Sep; 48(3): 305-9. (IF: 3.885)

34. Baral R, Patnaik S, Das BR. Co-overexpression of p53 and c-myc proteins linked with advanced stages of betel- and tobacco-related oral squamous cell carcinomas from eastern India. Eur J Oral Sci. 1998 Oct; 106(5): 907-13. (IF: 2.612)

35. Nayak BK, Patnaik S, Das BR. Rearrangement of the p53 gene in human breast tumors. Biochem Biophys Res Commun. 1998 Apr 17; 245(2): 388-91. (IF: 3.575)



Books :
1. Chakraborty, R., & Patnaik, S. (2023). Epigenetic regulations in inflammatory diseases. In Elsevier eBooks (pp. 585–613). https://doi.org/10.1016/b978-0-12-823931-5.00014-1

2. Berehu, H. M., Anupriya, S., & Patnaik, S. (2022). Nanotechnology-Based Therapeutics in ROS-Induced Cancer. In Handbook of Oxidative Stress in Cancer: Therapeutic Aspects (pp. 3039–3058). https://doi.org/10.1007/978-981-16-5422-0_254

3. Patnaik, S. (2015). Nanomedicine Magic Bullet for Human Cancer. In Advances in Chemical and materials engineering book series (pp. 167–191). IGI Global. https://doi.org/10.4018/978-1-4666-6363-3.ch009