Bhawna Gupta

Assistant Professor

Dr Gupta completed her doctoral studies at IGIB and University of Delhi in 2008 and worked diligently for understanding the role of immune cells in diseases and homeostasis. She gained a vast experience during her postdoctoral tenure while working at different international laboratories including CHUV, Lausanne, Switzerland; Dept of Bichemistry, University of Lausanne, Switzerland and Biocity, Finland. She worked to understand tumor immunology, human innate/adaptive immune responses during diseased conditions and published a number of peer reviewed scientific research articles and patents. She currently has a research laboratory at the School of Biotechnology wherein, together with her research team of PhD students and clinicians, she works to understand the pathogenesis, progression, diagnosis and prognosis of autoimmune diseases with special emphasis on autoimmune inflammatory joint disorder rheumatoid arthritis. Her research project has been constantly funded by a number of government research funding agencies and consultancy firms. Using her expertise, Dr Gupta has been teaching and training graduate and post graduate students at the School of Biotechnology since 2014. She has been helping students learn the concepts and techniques needed to understand human immunology, cellular processes, human genomics and proteomics. Using her competence she has been as well training the students to master effective communication skills and discern the correct ways of writing scientific research articles. Dr Gupta has been remarkably managing the hostel facilities for the girls studying at the School of Biotechnology.

Profile Links

Email :
[email protected]
Scopus Id :
56555827100
Google Scholar :
https://scholar.google.com/citations?user=AF-fRxIAAAAJ&hl=en&oi=ao

Social Links

Educational Qualification
Ph.D

Projects
  1. Identifying Mitochondrial Dysfunction as the regulatory mechanism in progression of Rheumatoid Arthritis and the associated therapeutic opportunities in the Indian case-control cohort, (DST-ECR/2015/000300); 45L. Early Career Research Grant.
  2. Integrative genomics approach to construct co-regulator-centered gene-regulatory networks underlying dendritic cell immune responses (DBT: BT/PR13501/GET/119/25/2015).
  3. To study the role of mesenchymal stem cells in pathogenesis of tuberculosis in bone marrow. DBT, co-PI, 2017.
  4. ZBTB10: a potential trigger for dendritic cell immune responses. SERB, CRG/2019/005893, 18.5 L.
  5. CONSULTANCY project: Bencos Research Pvt Ltd, Mumbai.


Administrative Responsibility
Superintendent of girls hostel, VC nominee for result declaration committee

Awards & Honours
  1. Scientific Manuscript Reviewer for International Journals like: Scientific Reports, BMC, Current Immunology Reviews
  2. Chairperson of Scientific Papers for IRACON 2017, 2018, 2019
  3. Dec 2002: CSIR-UGC Award for Research Fellowship and NET.
  4. Year 2001: Jawaharlal Nehru merit cum means scholarship for life sciences.
  5. Year 2000: Miranda House scholarship


Memberships
Indian Chamber of Commerce

Outreach Activity
Scientific advisor of science fair at Sai International School
Journals/Conferences :
1.Altered mitochondrial proteome and functional dynamics in patients with rheumatoid arthritis. Khanna, S., Padhan, P., Jaiswala, KS., Jain, AP., Ghosh, A., Tripathy, A., Gowda, H., Raghav, S & Gupta, B. (2020) Altered mitochondrial proteome and functional dynamics in patients with rheumatoid arthritis. Mitochondrion. 2020
2.Ahad,A., Stevanin, M., Smita, S., Mishra, GP., Gupta, D., Waszak,S., Sarkar, UA., Basak, S., Gupta, B., Acha-Orbea,H & Raghav, SK. (2019) NCoR1: Putting the Brakes on the Dendritic Cell Immune Tolerance. iScience 19, 996–1011, September 27, 2019
3.Smita,S., Ahad, A., Ghosh, A., Biswas, VK., Koga, MM., Gupta, B., Acha-Orbea, H & Raghav, SK. (2018). Importance of EMT Factor ZEB1 in cDC1 “MutuDC Line” Mediated Induction of Th1 Immune Response. Front. Immunol., 13 November 2018.
4.Khanna, S., Padhan, P., Das, S., Jaiswal, KS., Tripathy, A., Smita, S., Tripathy, SK., Raghav, SK & Gupta, B. (2018). A Simple Colorimetric Method for Naked-Eye Detection of Circulating Cell-Free DNA Using Unlabelled Gold Nanoparticles. ChemistrySelect 3(41):11541-11551, 2018
5.Khanna, S., Jaiswal, KS & Gupta, B. (2018). Disease-Modifying Antirheumatic Diets: The New Treatment Modalities for Rheumatoid Arthritis. EMJ Rheumatol. 2018;5[1]:93-99.
6.Khanna, S., Jaiswal, KS & Gupta, B. (2018). Managing Rheumatoid Arthritis with Dietary Interventions. Front. Nutr. 4:52.
7.Tripathy,A., Khanna, S., Padhan, P., Smita, S., Raghav, S & Gupta, B. (2017). Direct recognition of LPS drive TLR4 expressing CD8+ T cell activation in patients with rheumatoid arthritis. Scientific Reports 7, Article number: 933 (2017).
8.Iancu EM, Gannon PO, Laurent J, Gupta B, Romero P, Michielin O, Romano E, Speiser DE and Rufer N. PLoS One. (2013). Persistence of EBV antigen-specific CD8 T cell clonotypes during homeostatic immune reconstitution in cancer patients. Oct 25;8(10):e78686.
9.Tahvanainen J*, Kylaniemi MK*, Gupta B, Lähdesmäki H, Kallonen T, Rajavuori A, Rasool O, Lahesmaa R. (2013). Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.J Biol Chem. 2013 Feb 1; 288 (5): 3048-58.
10.Gupta B, Iancu EM, Gannon PO, Wieckowski S, Baitsch L, Speiser DE, Rufer N. Simultaneous coexpression of memory-related and effector-related genes by individual human CD8 T cells depends on antigen specificity and differentiation. (2012) J Immunother. 2012 Jul; 35 (6): 488-501.
11.Tuomela S, Salo V, Tripathi SK, Chen Z, Laurila K, Gupta B, Äijö T, Oikari L, Stockinger B, Lähdesmäki H, Lahesmaa R. Identification of early gene expression changes during human Th17 cell differentiation. (2012) Blood. 2012 Jun 7; 119 (23): e151-60.
12.Speiser DE*, Wieckowski S*, Gupta B, Iancu EM, Baumgaertner P, Michielin O, Romero P, and Rufer N. *equal contribution. Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes. (2011). Proc Natl Acad Sci U S A. 2011 Sep 13; 108 (37): 15318-23.

Books :
1.Das HR, Raghav S, Gupta B and Das RH. Anti-inflammatory compounds from medicinal plant Ruta graveolens. Acta Hort. 2007 756, 389- 398 (2007)
2.Gupta, B., Jaiswal, KS., Ghosh, A & Raghav, SK. Epigenetics and Epigenomics Analysis for Autoimmune Diseases. January 2019. DOI: 10.1016/B978-0-12-814513-5.00022-2. Elsevier. In book: Computational Epigenetics and Diseases.
3.Gupta, B., Tripathy, A & Jaiswal, KS. RNA and autoimmune diseases. (2020), Elsevier.